Anti-MARCH9 Antibody (CAB10596)
- SKU:
- CAB10596
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-MARCH9 Antibody |
抗体コード: | CAB10596 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 277-346 of human MARCH9 (NP_612405.2). |
申し込み: | WB |
推奨希釈: | WB 1:1000 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-251MG, A-549, 293T, Mouse intestine, Mouse kidney, Mouse eye, Rat kidney, Rat eye |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 277-346 of human MARCH9 (NP_612405.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | GTAG KSGP RNSR TGPT SGAT SRPP AAQR MRTL LPQR CGYT ILHL LGQL RPPD ARSS SHSG REVV MRVT TV |
遺伝子ID: | 92979 |
Uniprot: | Q86YJ5 |
セルラーロケーション: | Golgi apparatus membrane, Lysosome membrane, Multi-pass membrane protein |
計算された分子量: | 25kDa/37kDa |
観察された分子量: | 43kDa |
同義語: | MARCH9, MARCH-IX, RNF179 |
バックグラウンド: |
UniProt Protein Function: | MARCH9: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase Chromosomal Location of Human Ortholog: 12q14.1 Cellular Component: Golgi stack; trans-Golgi network |
NCBI Summary: | MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]).[supplied by OMIM, Apr 2010] |
UniProt Code: | Q86YJ5 |
NCBI GenInfo Identifier: | 74759533 |
NCBI Gene ID: | 92979 |
NCBI Accession: | Q86YJ5.2 |
UniProt Secondary Accession: | Q86YJ5,Q86VN5, Q96GG2, B2R9U9, |
UniProt Related Accession: | Q86YJ5 |
Molecular Weight: | 38kDa |
NCBI Full Name: | E3 ubiquitin-protein ligase MARCH9 |
NCBI Synonym Full Names: | membrane associated ring-CH-type finger 9 |
NCBI Official Symbol: | MARCH9 |
NCBI Official Synonym Symbols: | RNF179; MARCH-IX |
NCBI Protein Information: | E3 ubiquitin-protein ligase MARCH9 |
UniProt Protein Name: | E3 ubiquitin-protein ligase MARCH9 |
UniProt Synonym Protein Names: | Membrane-associated RING finger protein 9; Membrane-associated RING-CH protein IX; MARCH-IX; RING finger protein 179; RING-type E3 ubiquitin transferase MARCH9Curated |
UniProt Gene Name: | MARCH9 |
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