Anti-MAOA Antibody (CAB14024)

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SKU:
CAB14024
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
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Description

system_update_altデータシートsystem_update_alt安全性データシート
抗体名:Anti-MAOA Antibody
抗体コード:CAB14024
抗体サイズ:20uL, 50uL, 100uL
申し込み:IF
反応性:Human
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MAOA (NP_000231.1).
申し込み:IF
推奨希釈:IF 1:50 - 1:200
反応性:Human
ポジティブサンプル:
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MAOA (NP_000231.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MENQ EKAS IAGH MFDV VVIG GGIS GLSA AKLL TEYG VSVL VLEA RDRV GGRT YTIR NEHV DYVD VGGA YVGP TQNR ILRL SKEL GIET YKVN VSER LVQY VKGK TYPF RGAF PPVW NPIA YLDY NNLW RTID NMGK EIPT DAPW EAQH ADKW DKMT MKEL IDKI CWTK TARR FAYL FVNI NVTS EPHE VSAL WFLW YVKQ CGGT TRIF SVTN GGQE RKFV GGSG QVSE RIMD LLGD QVKL NHPV THVD QSSD NIII ETLN
遺伝子ID:4128
Uniprot:P21397
セルラーロケーション:Cytoplasmic side, Mitochondrion outer membrane, Single-pass type IV membrane protein
計算された分子量:44kDa/59kDa
観察された分子量:Refer to figures
同義語:MAOA, BRNRS, MAO-A
バックグラウンド:This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
UniProt Protein Function:MAOA: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are the cause of Brunner syndrome (BRUNS). Brunner syndrome is a form of X-linked non- dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Belongs to the flavin monoamine oxidase family.
UniProt Protein Details:

Protein type:EC 1.4.3.4; Membrane protein, integral; Amino Acid Metabolism - tryptophan; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - histidine; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - glycine, serine and threonine; Oxidoreductase; Amino Acid Metabolism - tyrosine

Chromosomal Location of Human Ortholog: Xp11.3

Cellular Component: mitochondrial outer membrane; mitochondrion; integral to membrane

Molecular Function:amine oxidase activity

Biological Process: synaptic transmission; biogenic amine metabolic process; neurotransmitter catabolic process; dopamine catabolic process; xenobiotic metabolic process; neurotransmitter secretion; neurotransmitter biosynthetic process

Disease: Brunner Syndrome

NCBI Summary:This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
UniProt Code:P21397
NCBI GenInfo Identifier:113978
NCBI Gene ID:4128
NCBI Accession:P21397.1
UniProt Secondary Accession:P21397,Q16426, B4DF46,
UniProt Related Accession:P21397
Molecular Weight:527
NCBI Full Name:Amine oxidase
NCBI Synonym Full Names:monoamine oxidase A
NCBI Official Symbol:MAOA  
NCBI Official Synonym Symbols:MAO-A  
NCBI Protein Information:amine oxidase [flavin-containing] A; amine oxidase [flavin-containing] A; monoamine oxidase type A
UniProt Protein Name:Amine oxidase [flavin-containing] A
UniProt Synonym Protein Names:Monoamine oxidase type A; MAO-A
Protein Family:Amine oxidase
UniProt Gene Name:MAOA  
UniProt Entry Name:AOFA_HUMAN
Anti-MAOA Antibody (CAB14024)Immunofluorescence analysis of HeLa cells using MAOA antibody (CAB14024). Blue: DAPI for nuclear staining.
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