Anti-MAD1 Antibody (CAB5098)
- SKU:
- CAB5098
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Frequently bought together:
Description
抗体名: | Anti-MAD1 Antibody |
抗体コード: | CAB5098 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human MAD1 |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa, 294T, Mouse spleen |
免疫原: | A synthesized peptide derived from human MAD1 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 8379 |
Uniprot: | Q9Y6D9 |
セルラーロケーション: | |
計算された分子量: | 80kDa |
観察された分子量: | 83KDa |
同義語: | MAD1, PIG9, TP53I9, TXBP181 |
バックグラウンド: | MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
UniProt Protein Function: | MAD1L1: a component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Expressed weakly at G0/G1 and highly at late S and G2/M phase. Induced by p53. Becomes hyperphosphorylated in late S through M phases or after mitotic spindle damage. Two alternatively spliced isoforms have been described. Defects in MAD1L1 are involved in the development and/or progression of various types of cancer. |
UniProt Protein Details: | Protein type:Cell cycle regulation; Cytoskeletal Chromosomal Location of Human Ortholog: 7p22 Cellular Component: kinetochore; centrosome; cytoplasm; spindle; nuclear pore; nucleus; cytosol; actin cytoskeleton Molecular Function:protein binding Biological Process: mitosis; cell division; mitotic cell cycle checkpoint; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle Disease: Prostate Cancer |
NCBI Summary: | MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y6D9 |
NCBI GenInfo Identifier: | 52783153 |
NCBI Gene ID: | 8379 |
NCBI Accession: | Q9Y6D9.2 |
UniProt Secondary Accession: | Q9Y6D9,Q13312, Q75MI0, Q86UM4, Q9UNH0, B3KR41, |
UniProt Related Accession: | Q9Y6D9 |
Molecular Weight: | 718 |
NCBI Full Name: | Mitotic spindle assembly checkpoint protein MAD1 |
NCBI Synonym Full Names: | MAD1 mitotic arrest deficient-like 1 (yeast) |
NCBI Official Symbol: | MAD1L1 |
NCBI Official Synonym Symbols: | MAD1; PIG9; TP53I9; TXBP181 |
NCBI Protein Information: | mitotic spindle assembly checkpoint protein MAD1; MAD1-like protein 1; tax-binding protein 181; tumor protein p53 inducible protein 9; mitotic checkpoint MAD1 protein homolog; mitotic arrest deficient 1-like protein 1; mitotic-arrest deficient 1, yeast, homolog-like 1 |
UniProt Protein Name: | Mitotic spindle assembly checkpoint protein MAD1 |
UniProt Synonym Protein Names: | Mitotic arrest deficient 1-like protein 1; MAD1-like protein 1; Mitotic checkpoint MAD1 protein homolog; HsMAD1; hMAD1; Tax-binding protein 181 |
Protein Family: | Mitotic spindle assembly checkpoint protein |
UniProt Gene Name: | MAD1L1 |
UniProt Entry Name: | MD1L1_HUMAN |
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