Anti-LILRB1 Antibody (CAB12827)
- SKU:
- CAB12827
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
抗体名: | Anti-LILRB1 Antibody |
抗体コード: | CAB12827 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human LILRB1 |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | Jurkat, Raji, A-431 |
免疫原: | Recombinant protein of human LILRB1 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 10859 |
Uniprot: | Q8NHL6 |
セルラーロケーション: | Membrane, Secreted, Single-pass type I membrane protein |
計算された分子量: | 49kDa/70kDa/71kDa |
観察された分子量: | 110kDa |
同義語: | LILRB1, CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7, PIR-B, PIRB |
バックグラウンド: | This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. |
NCBI Summary: | This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8NHL6 |
NCBI GenInfo Identifier: | 37537910 |
NCBI Gene ID: | 10859 |
NCBI Accession: | Q8NHL6.1 |
UniProt Secondary Accession: | Q8NHL6,O75024, O75025, Q8NHJ9, Q8NHK0, A2IXV4, A8MXT0 |
UniProt Related Accession: | Q8NHL6 |
Molecular Weight: | 49,356 Da |
NCBI Full Name: | Leukocyte immunoglobulin-like receptor subfamily B member 1 |
NCBI Synonym Full Names: | leukocyte immunoglobulin like receptor B1 |
NCBI Official Symbol: | LILRB1 |
NCBI Official Synonym Symbols: | ILT2; LIR1; MIR7; PIRB; CD85J; ILT-2; LIR-1; MIR-7; PIR-B |
NCBI Protein Information: | leukocyte immunoglobulin-like receptor subfamily B member 1 |
UniProt Protein Name: | Leukocyte immunoglobulin-like receptor subfamily B member 1 |
UniProt Synonym Protein Names: | CD85 antigen-like family member J; Immunoglobulin-like transcript 2; ILT-2; Monocyte/macrophage immunoglobulin-like receptor 7; MIR-7; CD_antigen: CD85j |
Protein Family: | Leukocyte immunoglobulin-like receptor subfamily |
UniProt Gene Name: | LILRB1 |
UniProt Entry Name: | LIRB1_HUMAN |
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