Anti-LASP1 Antibody (CAB3941)
- SKU:
- CAB3941
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-LASP1 Antibody |
抗体コード: | CAB3941 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-205 of human LASP1 (NP_006139.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:1000 - 1:3000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | A-549, BT-474, SKOV3, U-87MG, LO2, Mouse liver, Mouse brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-205 of human LASP1 (NP_006139.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | RMGP SGGE GMEP ERRD SQDG SSYR RPLE QQQP HHIP TSAP VYQQ PQQQ PVAQ SYGG YKEP AAPV SIQR SAPG GGGK |
遺伝子ID: | 3927 |
Uniprot: | Q14847 |
セルラーロケーション: | Cytoplasm, cell cortex, cytoskeleton |
計算された分子量: | 23kDa/29kDa/36kDa |
観察された分子量: | 37kDa |
同義語: | LASP1, Lasp-1, MLN50 |
バックグラウンド: | This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. |
UniProt Protein Function: | Lasp-1: a member of the LIM protein subfamily, characterized by a LIM motif and SH3 domain. Functions as an actin-binding protein, possibly in cytoskeletal organization. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 17q11-q21.3 Cellular Component: cortical actin cytoskeleton; focal adhesion Molecular Function:actin filament binding; ion transmembrane transporter activity; protein binding; SH3/SH2 adaptor activity; zinc ion binding Biological Process: ion transport; positive regulation of signal transduction |
NCBI Summary: | This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012] |
UniProt Code: | Q14847 |
NCBI GenInfo Identifier: | 3122342 |
NCBI Gene ID: | 3927 |
NCBI Accession: | Q14847.2 |
UniProt Secondary Accession: | Q14847,Q96ED2, Q96IG0, B4DGQ0, |
UniProt Related Accession: | Q14847 |
Molecular Weight: | 23,181 Da |
NCBI Full Name: | LIM and SH3 domain protein 1 |
NCBI Synonym Full Names: | LIM and SH3 protein 1 |
NCBI Official Symbol: | LASP1 |
NCBI Official Synonym Symbols: | MLN50; Lasp-1 |
NCBI Protein Information: | LIM and SH3 domain protein 1 |
UniProt Protein Name: | LIM and SH3 domain protein 1 |
UniProt Synonym Protein Names: | Metastatic lymph node gene 50 protein; MLN 50 |
Protein Family: | LIM and SH3 domain protein |
UniProt Gene Name: | LASP1 |
UniProt Entry Name: | LASP1_HUMAN |
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