Anti-LARS Antibody (CAB14890)
- SKU:
- CAB14890
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-LARS Antibody |
抗体コード: | CAB14890 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human LARS (NP_064502.9). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | K-562, HeLa, 293T |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human LARS (NP_064502.9). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAER KGTA KVDF LKKI EKEI QQKW DTER VFEV NASN LEKQ TSKG KYFV TFPY PYMN GRLH LGHT FSLS KCEF AVGY QRLK GKCC LFPF GLHC TGMP IKAC ADKL KREI ELYG CPPD FPDE EEEE EETS VKTE DIII KDKA KGKK SKAA AKAG SSKY QWGI MKSL GLSD EEIV KFSE AEHW LDYF PPLA IQDL KRMG LKVD WRRS FITT DVNP YYDS FVRW QFLT LRER NKIK FGKR YTIY SPKD GQPC MDHD RQTG EGVG PQEY TLLK LK |
遺伝子ID: | 51520 |
Uniprot: | Q9P2J5 |
セルラーロケーション: | Cytoplasm |
計算された分子量: | 55kDa/128kDa/134kDa |
観察された分子量: | 134kDa |
同義語: | LARS, HSPC192, ILFS1, LARS1, LEURS, LEUS, LFIS, LRS, PIG44, RNTLS, hr025Cl |
バックグラウンド: | This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. |
UniProt Protein Function: | LARS: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. Belongs to the class-I aminoacyl-tRNA synthetase family. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Ligase; Translation; EC 6.1.1.4 Chromosomal Location of Human Ortholog: 5q32 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:leucine-tRNA ligase activity; protein binding Biological Process: leucyl-tRNA aminoacylation; tRNA aminoacylation for protein translation Disease: Infantile Liver Failure Syndrome 1 |
NCBI Summary: | This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015] |
UniProt Code: | Q9P2J5 |
NCBI GenInfo Identifier: | 48428689 |
NCBI Gene ID: | 51520 |
NCBI Accession: | Q9P2J5.2 |
UniProt Secondary Accession: | Q9P2J5,Q2TU79, Q9NSE1, A2RRR4, A7E266, B4DJ10, |
UniProt Related Accession: | Q9P2J5 |
Molecular Weight: | 55,295 Da |
NCBI Full Name: | Leucine--tRNA ligase, cytoplasmic |
NCBI Synonym Full Names: | leucyl-tRNA synthetase |
NCBI Official Symbol: | LARS |
NCBI Official Synonym Symbols: | LRS; LEUS; LFIS; ILFS1; LARS1; LEURS; PIG44; RNTLS; HSPC192; hr025Cl |
NCBI Protein Information: | leucine--tRNA ligase, cytoplasmic |
UniProt Protein Name: | Leucine--tRNA ligase, cytoplasmic |
UniProt Synonym Protein Names: | Leucyl-tRNA synthetase; LeuRS |
Protein Family: | Leucine--tRNA ligase |
UniProt Gene Name: | LARS |
UniProt Entry Name: | SYLC_HUMAN |
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