Anti-KRT81 Antibody (CAB3940)
- SKU:
- CAB3940
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-KRT81 Antibody |
抗体コード: | CAB3940 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-390 of human KRT81 (NP_002272.2). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | Raji, A-549 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-390 of human KRT81 (NP_002272.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | RRLY EEEI LILQ SHIS DTSV VVKL DNSR DLNM DCII AEIK AQYD DIVT RSRA EAES WYRS KCEE MKAT VIRH GETL RRTK EEIN ELNR MIQR LTAE VENA KCQN SKLE AAVA QSEQ QGEA ALSD ARCK LAEL EGAL QKAK QDMA CLIR EYQ |
遺伝子ID: | 3887 |
Uniprot: | Q14533 |
セルラーロケーション: | |
計算された分子量: | 54kDa |
観察された分子量: | 55kDa |
同義語: | KRT81, HB1, Hb-1, KRTHB1, MLN137, ghHkb1, hHAKB2-1 |
バックグラウンド: | The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. |
UniProt Protein Function: | K81: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 12q13 Cellular Component: extracellular space; keratin filament Molecular Function:protein binding; structural molecule activity Disease: Monilethrix |
NCBI Summary: | The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14533 |
NCBI GenInfo Identifier: | 311033435 |
NCBI Gene ID: | 3887 |
NCBI Accession: | Q14533.3 |
UniProt Secondary Accession: | Q14533,Q14846, Q16274, Q17R48, Q8WU52, Q9BR74, |
UniProt Related Accession: | Q14533 |
Molecular Weight: | 505 |
NCBI Full Name: | Keratin, type II cuticular Hb1 |
NCBI Synonym Full Names: | keratin 81 |
NCBI Official Symbol: | KRT81 |
NCBI Official Synonym Symbols: | HB1; Hb-1; KRTHB1; MLN137; ghHkb1; hHAKB2-1 |
NCBI Protein Information: | keratin, type II cuticular Hb1; K81; ghHb1; MLN 137; keratin-81; hair keratin K2.9; type-II keratin Kb21; keratin, hair, basic, 1; hard keratin, type II, 1; type II hair keratin Hb1; metastatic lymph node 137 gene protein |
UniProt Protein Name: | Keratin, type II cuticular Hb1 |
UniProt Synonym Protein Names: | Hair keratin K2.9; Keratin, hair, basic, 1; Keratin-81; K81; Metastatic lymph node 137 gene protein; MLN 137; Type II hair keratin Hb1; Type-II keratin Kb21; ghHKb1; ghHb1 |
Protein Family: | Keratin |
UniProt Gene Name: | KRT81 |
UniProt Entry Name: | KRT81_HUMAN |
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