Anti-KREMEN2 Antibody (CAB16202)
- SKU:
- CAB16202
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-KREMEN2 Antibody |
抗体コード: | CAB16202 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-360 of human KREMEN2 (NP_078783.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse brain, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-360 of human KREMEN2 (NP_078783.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | GQLC GGDG RLGV YEVS VGSC QGNW TAPQ GVIY SPDF PDEY GPDR NCSW ALGP PGAA LELT FRLF ELAD PRDR LELR DAAS GSLL RAFD GARP PPSG PLRL GTAA LLLT FRSD ARGH AQGF ALTY RGLQ DAAE DPEA PEGS AQTP AAPL DGAN VSCS PRPG A |
遺伝子ID: | 79412 |
Uniprot: | Q8NCW0 |
セルラーロケーション: | |
計算された分子量: | 40kDa/42kDa/44kDa/45kDa/48kDa |
観察された分子量: | 48kDa |
同義語: | KREMEN2, KRM2 |
バックグラウンド: | This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. |
UniProt Protein Function: | KREMEN2: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: membrane; early endosome membrane; plasma membrane; integral to membrane Biological Process: Wnt receptor signaling pathway; cell communication |
NCBI Summary: | This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q8NCW0 |
NCBI GenInfo Identifier: | 27437008 |
NCBI Gene ID: | 79412 |
NCBI Accession: | NP_757384.1 |
UniProt Secondary Accession: | Q8NCW0,Q8N2J4, Q8NCW1, Q96GL8, Q9BTP9, B4DXF6, I3L2S2 |
UniProt Related Accession: | Q8NCW0 |
Molecular Weight: | 40,433 Da |
NCBI Full Name: | kremen protein 2 isoform d |
NCBI Synonym Full Names: | kringle containing transmembrane protein 2 |
NCBI Official Symbol: | KREMEN2 |
NCBI Official Synonym Symbols: | KRM2 |
NCBI Protein Information: | kremen protein 2 |
UniProt Protein Name: | Kremen protein 2 |
UniProt Synonym Protein Names: | Dickkopf receptor 2; Kringle domain-containing transmembrane protein 2; Kringle-containing protein marking the eye and the nose |
Protein Family: | Kremen protein |
UniProt Gene Name: | KREMEN2 |
UniProt Entry Name: | KREM2_HUMAN |
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