Anti-KCNK4 Antibody (CAB12217)
- SKU:
- CAB12217
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-KCNK4 Antibody |
抗体コード: | CAB12217 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-90 of human KCNK4 (NP_201567.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | HepG2 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-90 of human KCNK4 (NP_201567.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | RALE QPHE QQAQ RELG EVRE KFLR AHPC VSDQ ELGL LIKE VADA LGGG ADPE TNST SNSS HSAW DL |
遺伝子ID: | 50801 |
Uniprot: | Q9NYG8 |
セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
計算された分子量: | 42kDa/45kDa |
観察された分子量: | 58kDa |
同義語: | KCNK4, K2p4.1, TRAAK, TRAAK1 |
バックグラウンド: | This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. |
UniProt Protein Function: | KCNK4: Voltage insensitive, instantaneous, outwardly rectifying potassium channel. Outward rectification is reversed at high external K(+) concentrations. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11q13 Cellular Component: plasma membrane; integral to membrane Molecular Function:potassium channel activity; voltage-gated ion channel activity Biological Process: synaptic transmission; potassium ion transport |
NCBI Summary: | Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NYG8 |
NCBI GenInfo Identifier: | 13124080 |
NCBI Gene ID: | 50801 |
NCBI Accession: | Q9NYG8.2 |
UniProt Secondary Accession: | Q9NYG8,Q96T94, B5TJL1, |
UniProt Related Accession: | Q9NYG8 |
Molecular Weight: | 42,704 Da |
NCBI Full Name: | Potassium channel subfamily K member 4 |
NCBI Synonym Full Names: | potassium channel, subfamily K, member 4 |
NCBI Official Symbol: | KCNK4 |
NCBI Official Synonym Symbols: | TRAAK; K2p4.1; TRAAK1 |
NCBI Protein Information: | potassium channel subfamily K member 4; K2P4.1 potassium channel; two pore K+ channel KT4.1; two pore K(+) channel KT4.1; two pore potassium channel KT4.1; TWIK-related arachidonic acid-stimulated potassium channel protein |
UniProt Protein Name: | Potassium channel subfamily K member 4 |
UniProt Synonym Protein Names: | TWIK-related arachidonic acid-stimulated potassium channel protein; TRAAK; Two pore potassium channel KT4.1 |
Protein Family: | Potassium channel subfamily |
UniProt Gene Name: | KCNK4 |
UniProt Entry Name: | KCNK4_HUMAN |
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