Anti-KCNIP2 Antibody (CAB7100)
- SKU:
- CAB7100
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-KCNIP2 Antibody |
抗体コード: | CAB7100 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human KCNIP2 (NP_775284.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse brain, Mouse heart, Mouse pancreas |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human KCNIP2 (NP_775284.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MRGQ GRKE SLSD SRDL DGSY DQLT GHPP GPTK KALK QRFL KLLP CCGP QALP SVSE NSVD DEFE LSTV CHRP EGLE QLQE QTKF TRKE LQ |
遺伝子ID: | 30819 |
Uniprot: | Q9NS61 |
セルラーロケーション: | Cell membrane, Lipid-anchor, Lipid-anchor |
計算された分子量: | 20kDa/21kDa/25kDa/26kDa/28kDa/30kDa/32kDa |
観察された分子量: | 24kDa |
同義語: | KCNIP2, KCHIP2 |
バックグラウンド: | This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. |
UniProt Protein Function: | KCNIP2: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. Belongs to the recoverin family. 9 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 10q24Cellular Component: voltage-gated potassium channel complex; cytoplasmMolecular Function: identical protein binding; protein binding; potassium channel regulator activity; protein N-terminus binding; calcium ion binding; ER retention sequence binding; A-type (transient outward) potassium channel activityBiological Process: synaptic transmission; muscle contraction; clustering of voltage-gated potassium channels; detection of calcium ion; signal transduction; regulation of heart contraction; potassium ion transport |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NS61 |
NCBI GenInfo Identifier: | 338817979 |
NCBI Gene ID: | 30819 |
NCBI Accession: | Q9NS61.3 |
UniProt Secondary Accession: | Q9NS61 |
UniProt Related Accession: | Q9NS61 |
Molecular Weight: | 24kDa |
NCBI Full Name: | Kv channel-interacting protein 2 |
NCBI Synonym Full Names: | potassium voltage-gated channel interacting protein 2 |
NCBI Official Symbol: | KCNIP2 |
NCBI Official Synonym Symbols: | KCHIP2 |
NCBI Protein Information: | Kv channel-interacting protein 2 |
UniProt Protein Name: | Kv channel-interacting protein 2 |
UniProt Synonym Protein Names: | A-type potassium channel modulatory protein 2; Cardiac voltage-gated potassium channel modulatory subunit; Potassium channel-interacting protein 2 |
Protein Family: | Kv channel-interacting protein |
UniProt Gene Name: | KCNIP2 |
UniProt Entry Name: | KCIP2_HUMAN |
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