Anti-KCND2 Antibody (CAB6203)
- SKU:
- CAB6203
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-KCND2 Antibody |
抗体コード: | CAB6203 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 501-630 of human KCND2 (NP_036413.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Rat |
ポジティブサンプル: | THP-1, Rat brain, Rat heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 501-630 of human KCND2 (NP_036413.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ESCM EVAT VNRP SSHS PSLS SQQG VTST CCSR RHKK TFRI PNAN VSGS HQGS IQEL STIQ IRCV ERTP LSNS RSSL NAKM EECV KLNC EQPY VTTA IISI PTPP VTTP EGDD RPES PEYS GGNI VRVS AL |
遺伝子ID: | 3751 |
Uniprot: | Q9NZV8 |
セルラーロケーション: | Cell junction, Cell membrane, Cell projection, Multi-pass membrane protein, Perikaryon, dendrite, dendritic spine, postsynaptic cell membrane, synapse |
計算された分子量: | 70kDa |
観察された分子量: | 82kDa |
同義語: | KCND2, KV4.2, RK5 |
バックグラウンド: | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. |
UniProt Protein Function: | Kv4.2: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Channel, potassium Chromosomal Location of Human Ortholog: 7q31 Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; integral to plasma membrane; integral to membrane; plasma membrane; dendritic spine; intrinsic to plasma membrane Molecular Function:protein binding; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; metal ion binding; A-type (transient outward) potassium channel activity Biological Process: regulation of action potential; synaptic transmission; protein homooligomerization |
NCBI Summary: | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NZV8 |
NCBI GenInfo Identifier: | 38258257 |
NCBI Gene ID: | 3751 |
NCBI Accession: | Q9NZV8.2 |
UniProt Secondary Accession: | Q9NZV8,O95012, O95021, Q2TBD3, Q9UBY7, Q9UN98, Q9UNH9 |
UniProt Related Accession: | Q9NZV8 |
Molecular Weight: | 630 |
NCBI Full Name: | Potassium voltage-gated channel subfamily D member 2 |
NCBI Synonym Full Names: | potassium voltage-gated channel, Shal-related subfamily, member 2 |
NCBI Official Symbol: | KCND2 |
NCBI Official Synonym Symbols: | RK5; KV4.2 |
NCBI Protein Information: | potassium voltage-gated channel subfamily D member 2; voltage-sensitive potassium channel; voltage-gated potassium channel subunit Kv4.2 |
UniProt Protein Name: | Potassium voltage-gated channel subfamily D member 2 |
UniProt Synonym Protein Names: | Voltage-gated potassium channel subunit Kv4.2 |
Protein Family: | Potassium voltage-gated channel subfamily |
UniProt Gene Name: | KCND2 |
UniProt Entry Name: | KCND2_HUMAN |
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