Anti-KATNA1 Antibody (CAB16491)
- SKU:
- CAB16491
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
抗体名: | Anti-KATNA1 Antibody |
抗体コード: | CAB16491 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human KATNA1 (NP_001191005.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:1000 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human KATNA1 (NP_001191005.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSLL MISE NVKL AREY ALLG NYDS AMVY YQGV LDQM NKYL YSVK DTYL QQKW QQVW QEIN VEAK HVKD IMKT LESF KLDS TPLK AAQH DLPA SEGE VWSM PVPV ERRP SPGP RKRQ SSQY SDPK SHGN RPST TVRV HRSS AQNV HNDR GKAV RCRE KKEQ NKGR EEK |
遺伝子ID: | 11104 |
Uniprot: | O75449 |
セルラーロケーション: | Cytoplasm, Midbody, centrosome, cytoskeleton, microtubule organizing center, spindle pole |
計算された分子量: | 35kDa/55kDa |
観察された分子量: |
同義語: | KATNA1 |
バックグラウンド: | Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
UniProt Protein Function: | KATNA1: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays, such as during disassembly of interphase microtubules at the G2-M transition. May also be required for microtubule release from the centrosome after nucleation. In mitotic spindles this could allow depolymerization of the microtubule end proximal to the centrosome, and subsequent poleward microtubule flux. In neurons, microtubule release within the cell body may allow their subsequent transport into neuronal processes by microtubule dependent motor proteins. This transport is required for axonal growth. Belongs to the AAA ATPase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Hydrolase; Motility/polarity/chemotaxis; EC 3.6.4.3 Chromosomal Location of Human Ortholog: 6q25.1 Cellular Component: cytoplasm; microtubule organizing center; midbody; nucleus; spindle; spindle pole Molecular Function:microtubule binding; microtubule-severing ATPase activity; protein binding; protein heterodimerization activity Biological Process: cytoplasmic microtubule organization and biogenesis |
NCBI Summary: | Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011] |
UniProt Code: | O75449 |
NCBI GenInfo Identifier: | 60390161 |
NCBI Gene ID: | 11104 |
NCBI Accession: | O75449.1 |
UniProt Secondary Accession: | O75449,Q5TFA8, Q5TFA9, Q86VN2, Q9NU52, E1P5A3, |
UniProt Related Accession: | O75449 |
Molecular Weight: | 35,319 Da |
NCBI Full Name: | Katanin p60 ATPase-containing subunit A1 |
NCBI Synonym Full Names: | katanin catalytic subunit A1 |
NCBI Official Symbol: | KATNA1 |
NCBI Protein Information: | katanin p60 ATPase-containing subunit A1 |
UniProt Protein Name: | Katanin p60 ATPase-containing subunit A1 |
UniProt Synonym Protein Names: | p60 katanin |
UniProt Gene Name: | KATNA1 |
UniProt Entry Name: | KTNA1_HUMAN |
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