Anti-JNK3 Antibody (CAB17408)
- SKU:
- CAB17408
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-JNK3 Antibody |
抗体コード: | CAB17408 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human JNK3. |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | mouse testis, rat testis |
免疫原: | Recombinant protein of human JNK3. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 5602 |
Uniprot: | P53779 |
セルラーロケーション: | Cytoplasm, Lipid-anchor, Membrane, Mitochondrion, Nucleus |
計算された分子量: | 48kDa/52kDa |
観察された分子量: | 52kDa |
同義語: | JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK, MAPK10 |
バックグラウンド: | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. |
UniProt Protein Function: | Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). |
NCBI Summary: | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015] |
UniProt Code: | P53779 |
NCBI GenInfo Identifier: | 2507196 |
NCBI Gene ID: | 5602 |
NCBI Accession: | P53779.2 |
UniProt Secondary Accession: | P53779,Q15707, Q49AP1, A6NFS3, A6NG28, B3KQ94, |
UniProt Related Accession: | P53779 |
Molecular Weight: | 31,933 Da |
NCBI Full Name: | Mitogen-activated protein kinase 10 |
NCBI Synonym Full Names: | mitogen-activated protein kinase 10 |
NCBI Official Symbol: | MAPK10 |
NCBI Official Synonym Symbols: | JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK |
NCBI Protein Information: | mitogen-activated protein kinase 10 |
UniProt Protein Name: | Mitogen-activated protein kinase 10 |
UniProt Synonym Protein Names: | MAP kinase p49 3F12; Stress-activated protein kinase 1b; SAPK1b; Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3 |
UniProt Gene Name: | MAPK10 |
UniProt Entry Name: | MK10_HUMAN |
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