Anti-IRF2 Antibody (CAB2558)
- SKU:
- CAB2558
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-IRF2 Antibody |
抗体コード: | CAB2558 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-349 of human IRF2 (NP_002190.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SW480, NIH/3T3 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-349 of human IRF2 (NP_002190.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | KKGK KPKT EKED KVKH IKQE PVES SLGL SNGV SDLS PEYA VLTS TIKN EVDS TVNI IVVG QSHL DSNI ENQE IVTN PPDI CQVV EVTT ESDE QPVS MSEL YPLQ ISPV SSYA ESET TDSV PSDE ESAE GRPH WRKR NIEG KQYL SNMG TRGS YLLP GMAS FVTS NKPD LQVT IKEE SNPV PYNS SWPP FQDL PLSS SMTP ASSS SRPD RETR ASVI KKTS DITQ ARVK SC |
遺伝子ID: | 3660 |
Uniprot: | P14316 |
セルラーロケーション: | Nucleus |
計算された分子量: | 39kDa |
観察された分子量: | 42kDa |
同義語: | IRF2, IRF-2 |
バックグラウンド: | IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. |
UniProt Protein Function: | IRF2: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity. By viruses and IFN. Expressed throughout the epithelium of the colon. Also expressed in lamina propria. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 4q34.1-q35.1 Cellular Component: nucleoplasm; focal adhesion; cytoplasm; cytosol Molecular Function:protein binding; DNA binding; transcription factor activity Biological Process: cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; blood coagulation |
NCBI Summary: | IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008] |
UniProt Code: | P14316 |
NCBI GenInfo Identifier: | 20141499 |
NCBI Gene ID: | 3660 |
NCBI Accession: | P14316.2 |
UniProt Secondary Accession: | P14316,Q6IAS7, Q96B99, D6RCK5, H0Y8S3, |
UniProt Related Accession: | P14316 |
Molecular Weight: | 39,156 Da |
NCBI Full Name: | Interferon regulatory factor 2 |
NCBI Synonym Full Names: | interferon regulatory factor 2 |
NCBI Official Symbol: | IRF2 |
NCBI Official Synonym Symbols: | IRF-2 |
NCBI Protein Information: | interferon regulatory factor 2 |
UniProt Protein Name: | Interferon regulatory factor 2 |
Protein Family: | Interferon regulatory factor |
UniProt Gene Name: | IRF2 |
UniProt Entry Name: | IRF2_HUMAN |
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