Anti-INSIG2 Antibody (CAB1992)
- SKU:
- CAB1992
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-INSIG2 Antibody |
抗体コード: | CAB1992 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human INSIG2 (NP_057217.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | 293T, Mouse kidney, Mouse spleen, Mouse brain |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human INSIG2 (NP_057217.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | QIQR NVTL FPPD VIAS IFSS AWWV PPCC GTAS AVIG LLYP CIDR HLGE PHKF KREW SSVM RCVA VFVG INHA SAKV DFDN NIQL SLTL AALS IGLW WTFD R |
遺伝子ID: | 51141 |
Uniprot: | Q9Y5U4 |
セルラーロケーション: | Endoplasmic reticulum membrane, Multi-pass membrane protein |
計算された分子量: | 24kDa |
観察された分子量: | 27kDa |
同義語: | INSIG2, INSIG-2 |
バックグラウンド: | The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. |
UniProt Protein Function: | Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. |
NCBI Summary: | The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y5U4 |
NCBI GenInfo Identifier: | 1008806542 |
NCBI Gene ID: | 51141 |
NCBI Accession: | NP_001308258.1 |
UniProt Secondary Accession: | Q9Y5U4,Q8TBI8, A8K5W8, |
UniProt Related Accession: | Q9Y5U4 |
Molecular Weight: | 24 |
NCBI Full Name: | insulin-induced gene 2 protein isoform a |
NCBI Synonym Full Names: | insulin induced gene 2 |
NCBI Official Symbol: | INSIG2 |
NCBI Official Synonym Symbols: | INSIG-2 |
NCBI Protein Information: | insulin-induced gene 2 protein |
UniProt Protein Name: | Insulin-induced gene 2 protein |
UniProt Gene Name: | INSIG2 |
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