Anti-IFNAR1 Antibody (RACO0179)
- SKU:
- RACO0179
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Conjugation:
- Unconjugated
Frequently bought together:
Description
商品名: | IFNAR1 Antibody |
Product SKU: | RACO0179 |
サイズ: | 50ul |
宿主種: | Human |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | A synthesized peptide derived from human IFNAR1 |
憲法: | Liquid |
ストレージバッファ: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
精製方法: | Affinity-chromatography |
抗体のクローン性: | Monoclonal |
アイソタイプ: | Rabbit IgG |
Conjugate: | Non-conjugated |
バックグラウンド: | Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). |
シノニム: | Interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1, IFNAR1, IFNAR |
UniProt Protein Function: | IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells. |
UniProt Protein Details: | Protein type:Receptor, cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane Molecular Function:protein binding; interferon receptor activity; interferon-alpha/beta receptor activity Biological Process: positive regulation of interferon-gamma production; cell surface receptor linked signal transduction; T cell activation; cytokine and chemokine mediated signaling pathway; response to virus; positive regulation of interleukin-1 beta secretion; interferon type I biosynthetic process; JAK-STAT cascade; defense response to virus |
NCBI Summary: | The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008] |
UniProt Code: | P17181 |
NCBI GenInfo Identifier: | 90110827 |
NCBI Gene ID: | 3454 |
NCBI Accession: | P17181.3 |
UniProt Secondary Accession: | P17181,Q53GW9, Q53H11, Q6PKD7, Q7M4L2, Q8WTZ2, B2R6L9 B4DNT3, D3DSF0, |
UniProt Related Accession: | P17181 |
Molecular Weight: | Calculated MW: 49kDa/56kDa/63kDaObserved MW: 70kDa |
NCBI Full Name: | Interferon alpha/beta receptor 1 |
NCBI Synonym Full Names: | interferon (alpha, beta and omega) receptor 1 |
NCBI Official Symbol: | IFNAR1 |
NCBI Official Synonym Symbols: | AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC |
NCBI Protein Information: | interferon alpha/beta receptor 1; CRF2-1; IFN-R-1; IFN-alpha/beta receptor 1; interferon-beta receptor 1; beta-type antiviral protein; alpha-type antiviral protein; type I interferon receptor 1; cytokine receptor class-II member 1; cytokine receptor family 2 member 1; interferon-alpha/beta receptor alpha chain |
UniProt Protein Name: | Interferon alpha/beta receptor 1 |
UniProt Synonym Protein Names: | Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1 |
Protein Family: | Interferon alpha/beta receptor |
UniProt Gene Name: | IFNAR1 |
UniProt Entry Name: | INAR1_HUMAN |