IFNAR1 Antibody (PACO04118)
- SKU:
- PACO04118
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | IFNAR1 Antibody |
抗体コード: | PACO04118 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | IHC:1:100-1:300, IF:1:200-1:1000 |
反応性: | Human |
免疫原: | synthesized peptide derived from human IFN-alpha/BetaRalpha around the non-phosphorylation site of Y466. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | IFNAR1; IFNAR; Interferon alpha/beta receptor 1; IFN-R-1; IFN-alpha/beta receptor 1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1 |
UniProt Protein Function: | IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells. |
UniProt Protein Details: | Protein type:Receptor, cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane Molecular Function:protein binding; interferon receptor activity; interferon-alpha/beta receptor activity Biological Process: positive regulation of interferon-gamma production; cell surface receptor linked signal transduction; T cell activation; cytokine and chemokine mediated signaling pathway; response to virus; positive regulation of interleukin-1 beta secretion; interferon type I biosynthetic process; JAK-STAT cascade; defense response to virus |
NCBI Summary: | The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008] |
UniProt Code: | P17181 |
NCBI GenInfo Identifier: | 90110827 |
NCBI Gene ID: | 3454 |
NCBI Accession: | P17181.3 |
UniProt Secondary Accession: | P17181,Q53GW9, Q53H11, Q6PKD7, Q7M4L2, Q8WTZ2, B2R6L9 B4DNT3, D3DSF0, |
UniProt Related Accession: | P17181 |
Molecular Weight: | Calculated MW: 49kDa/56kDa/63kDaObserved MW: 70kDa |
NCBI Full Name: | Interferon alpha/beta receptor 1 |
NCBI Synonym Full Names: | interferon (alpha, beta and omega) receptor 1 |
NCBI Official Symbol: | IFNAR1 |
NCBI Official Synonym Symbols: | AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC |
NCBI Protein Information: | interferon alpha/beta receptor 1; CRF2-1; IFN-R-1; IFN-alpha/beta receptor 1; interferon-beta receptor 1; beta-type antiviral protein; alpha-type antiviral protein; type I interferon receptor 1; cytokine receptor class-II member 1; cytokine receptor family 2 member 1; interferon-alpha/beta receptor alpha chain |
UniProt Protein Name: | Interferon alpha/beta receptor 1 |
UniProt Synonym Protein Names: | Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1 |
Protein Family: | Interferon alpha/beta receptor |
UniProt Gene Name: | IFNAR1 |
UniProt Entry Name: | INAR1_HUMAN |