Anti-ICT1 Antibody (CAB11590)
- SKU:
- CAB11590
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-ICT1 Antibody |
抗体コード: | CAB11590 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-206 of human ICT1 (NP_001536.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Raji, HT-29, 293T, B cells, SKOV3, Mouse lung, Mouse kidney, Mouse brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-206 of human ICT1 (NP_001536.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | LHKQ KDGT EFKS IYSL DKLY PESQ GSDT AWRV PNGA KQAD SDIP LDRL TISY CRSS GPGG QNVN KVNS KAEV RFHL ATAE WIAE PVRQ KIAI THKN KINR LGEL ILTS ESSR YQFR NLAD CLQK IRDM ITEA SQTP KEPT KEDV KLHR IRIE NMNR ERLR QKRI HSAV KTSR RVDM D |
遺伝子ID: | 3396 |
Uniprot: | Q14197 |
セルラーロケーション: | Mitochondrion |
計算された分子量: | 23kDa |
観察された分子量: | 24kDa |
同義語: | MRPL58, DS-1, DS1, ICT1, MRP-L58 |
バックグラウンド: | The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | ICT1: Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. Belongs to the prokaryotic/mitochondrial release factor family. ICT1 subfamily. |
UniProt Protein Details: | Protein type:EC 3.1.1.29; Mitochondrial Chromosomal Location of Human Ortholog: 17q25.1 Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunit; mitochondrial matrix; mitochondrion Molecular Function:aminoacyl-tRNA hydrolase activity; translation release factor activity, codon nonspecific |
NCBI Summary: | The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014] |
UniProt Code: | Q14197 |
NCBI GenInfo Identifier: | 6015033 |
NCBI Gene ID: | 3396 |
NCBI Accession: | Q14197.1 |
UniProt Secondary Accession: | Q14197,Q53HM7, Q53Y11, B2RAD1, |
UniProt Related Accession: | Q14197 |
Molecular Weight: | 24kDa |
NCBI Full Name: | Peptidyl-tRNA hydrolase ICT1, mitochondrial |
NCBI Synonym Full Names: | mitochondrial ribosomal protein L58 |
NCBI Official Symbol: | MRPL58 |
NCBI Official Synonym Symbols: | DS1; DS-1; ICT1; MRP-L58 |
NCBI Protein Information: | peptidyl-tRNA hydrolase ICT1, mitochondrial |
UniProt Protein Name: | Peptidyl-tRNA hydrolase ICT1, mitochondrial |
UniProt Synonym Protein Names: | 39S ribosomal protein L58, mitochondrial |
Protein Family: | 1-acylglycerol-3-phosphate O-acyltransferase |
UniProt Gene Name: | MRPL58 |
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