Anti-IARS Antibody (CAB10190)
- SKU:
- CAB10190
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-IARS Antibody |
抗体コード: | CAB10190 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1158-1262 of human IARS (NP_002152.2). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, HepG2, HT-29, HL-60, Jurkat |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1158-1262 of human IARS (NP_002152.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | SAPS LINS SSTL LCQY INLQ LLNA KPQE CLMG TVGT LLLE NPLG QNGL THQG LLYE AAKV FGLR SRKL KLFL NETQ TQEI TEDI PVKT LNMK TVYV SVLP TTAD F |
遺伝子ID: | 3376 |
Uniprot: | P41252 |
セルラーロケーション: | Cytoplasm |
計算された分子量: | 144kDa |
観察された分子量: | 144kDa |
同義語: | IARS, GRIDHH, IARS1, ILERS, ILRS, IRS, PRO0785 |
バックグラウンド: | Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. |
UniProt Protein Function: | IARS: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Two alternatively spliced variants have been isolated that represent alternate 5' UTRs. [provided by RefSeq, Jul 2008] |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Aminoacyl-tRNA synthetase; EC 6.1.1.5; Ligase; Translation; Translation regulation Chromosomal Location of Human Ortholog: 9q22.31 Cellular Component: cytoplasm; cytosol; membrane Molecular Function:GTPase binding; isoleucine-tRNA ligase activity; protein binding Biological Process: isoleucyl-tRNA aminoacylation; osteoblast differentiation; tRNA aminoacylation for protein translation Disease: Growth Retardation, Intellectual Developmental Disorder, Hypotonia, And Hepatopathy |
NCBI Summary: | Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012] |
UniProt Code: | P41252 |
NCBI GenInfo Identifier: | 239938717 |
NCBI Gene ID: | 3376 |
NCBI Accession: | P41252.2 |
UniProt Secondary Accession: | P41252,Q5TCD0, Q7Z3T4, Q9H588, A8KAE9, |
UniProt Related Accession: | P41252 |
Molecular Weight: | 144kDa |
NCBI Full Name: | Isoleucine--tRNA ligase, cytoplasmic |
NCBI Synonym Full Names: | isoleucyl-tRNA synthetase |
NCBI Official Symbol: | IARS |
NCBI Official Synonym Symbols: | IRS; ILRS; IARS1; ILERS; GRIDHH; PRO0785 |
NCBI Protein Information: | isoleucine--tRNA ligase, cytoplasmic |
UniProt Protein Name: | Isoleucine--tRNA ligase, cytoplasmic |
UniProt Synonym Protein Names: | Isoleucyl-tRNA synthetase; IRS; IleRS |
UniProt Gene Name: | IARS |
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