Anti-Hsp47 Antibody (CAB11698)
- SKU:
- CAB11698
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-Hsp47 Antibody |
抗体コード: | CAB11698 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human Hsp47 |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa, NIH/3T3 |
免疫原: | A synthesized peptide derived from human Hsp47 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 871 |
Uniprot: | P50454 |
セルラーロケーション: | |
計算された分子量: | 46kDa |
観察された分子量: | 46KDa |
同義語: | AsTP3, CBP1, CBP2, HSP47, OI10, PIG14, PPROM, RA-A47, SERPINH2, gp46 |
バックグラウンド: | This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011] |
UniProt Protein Function: | SERPINH1: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. Defects in SERPINH1 are the cause of osteogenesis imperfecta type 10 (OI10). A connective tissue disorder characterized by bone fragility, low bone mass, bowing of limbs due to multiple fractures, short limb dwarfism and blue sclerae. Belongs to the serpin family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 11q13.5 Cellular Component: extracellular space; endoplasmic reticulum; endoplasmic reticulum lumen; ER-Golgi intermediate compartment Molecular Function:serine-type endopeptidase inhibitor activity; collagen binding; unfolded protein binding Biological Process: extracellular matrix organization and biogenesis; collagen fibril organization; protein maturation; collagen biosynthetic process; response to unfolded protein Disease: Osteogenesis Imperfecta, Type X; Preterm Premature Rupture Of The Membranes |
NCBI Summary: | This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011] |
UniProt Code: | P50454 |
NCBI GenInfo Identifier: | 20141241 |
NCBI Gene ID: | 871 |
NCBI Accession: | P50454.2 |
UniProt Secondary Accession: | P50454,P29043, Q5XPB4, Q6NSJ6, Q8IY96, Q9NP88, B3KVJ3 |
UniProt Related Accession: | P50454 |
Molecular Weight: | 418 |
NCBI Full Name: | Serpin H1 |
NCBI Synonym Full Names: | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) |
NCBI Official Symbol: | SERPINH1 |
NCBI Official Synonym Symbols: | CBP1; CBP2; OI10; gp46; AsTP3; HSP47; PIG14; PPROM; RA-A47; SERPINH2 |
NCBI Protein Information: | serpin H1; colligin-1; colligin-2; 47 kDa heat shock protein; arsenic-transactivated protein 3; rheumatoid arthritis antigen A-47; cell proliferation-inducing gene 14 protein; rheumatoid arthritis-related antigen RA-A47; serine (or cysteine) proteinase in |
UniProt Protein Name: | Serpin H1 |
UniProt Synonym Protein Names: | 47 kDa heat shock protein; Arsenic-transactivated protein 3; AsTP3; Cell proliferation-inducing gene 14 protein; Collagen-binding protein; Colligin; Rheumatoid arthritis-related antigen RA-A47 |
UniProt Gene Name: | SERPINH1 |
UniProt Entry Name: | SERPH_HUMAN |