Anti-HSD3B1 Antibody (CAB8035)
- SKU:
- CAB8035
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | HSD3B1 Rabbit Polyclonal Antibody |
抗体コード: | CAB8035 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human HSD3B1 (NP_000853.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:1000 IF 1:20 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | A375 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human HSD3B1 (NP_000853.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MTGW SCLV TGAG GFLG QRII RLLV KEKE LKEI RVLD KAFG PELR EEFS KLQN KTKL TVLE GDIL DEPF LKRA CQDV SVII HTAC IIDV FGVT HRES IMNV NVKG TQLL LEAC VQAS VPVF IYTS SIEV AGPN SYKE IIQN GHEE EPLE NTWP APYP HSKK LAEK AVLA ANGW NLKN GGTL YTCA LRPM YIYG EGSR FLSA SINE ALNN NGIL SSVG KFST VNPV YVGN VAWA HILA LRAL QDPK KAPS IRGQ FYYI SDDT PHQS YDNL NYTL SKEF GLRL DSRW SFPL SL |
遺伝子ID: | 3283 |
Uniprot: | P14060 |
セルラーロケーション: | Endoplasmic reticulum membrane, Mitochondrion membrane, Single-pass membrane protein |
計算された分子量: | 42kDa |
観察された分子量: | 50kDa |
同義語: | HSD3B1, 3BETAHSD, HSD3B, HSDB3, HSDB3A, I, SDR11E1 |
バックグラウンド: | The protein encoded by this gene is an enzyme that catalyzes the oxidative conversion of delta-5-3-beta-hydroxysteroid precursors into delta-4-ketosteroids, which leads to the production of all classes of steroid hormones. The encoded protein also catalyzes the interconversion of 3-beta-hydroxy- and 3-keto-5-alpha-androstane steroids. |
UniProt Protein Function: | HSD3B1: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17- alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone. Belongs to the 3-beta-HSD family. |
UniProt Protein Details: | Protein type:Lipid Metabolism - androgen and estrogen; EC 5.3.3.1; Membrane protein, integral; EC 1.1.1.145; Oxidoreductase; Lipid Metabolism - C21-steroid hormone; Isomerase; Mitochondrial Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: endoplasmic reticulum membrane; mitochondrial inner membrane; mitochondrial intermembrane space; smooth endoplasmic reticulum membrane Molecular Function:3-beta-hydroxy-delta5-steroid dehydrogenase activity; steroid delta-isomerase activity Biological Process: androgen biosynthetic process; estrogen biosynthetic process; glucocorticoid biosynthetic process; mineralocorticoid biosynthetic process; steroid biosynthetic process |
NCBI Summary: | The protein encoded by this gene is an enzyme that catalyzes the oxidative conversion of delta-5-3-beta-hydroxysteroid precursors into delta-4-ketosteroids, which leads to the production of all classes of steroid hormones. The encoded protein also catalyzes the interconversion of 3-beta-hydroxy- and 3-keto-5-alpha-androstane steroids. [provided by RefSeq, Jun 2016] |
UniProt Code: | P14060 |
NCBI GenInfo Identifier: | 112767 |
NCBI Gene ID: | 3283 |
NCBI Accession: | P14060.2 |
UniProt Secondary Accession: | P14060,Q14545, Q8IV65, A8K691, |
UniProt Related Accession: | P14060 |
Molecular Weight: | 42,252 Da |
NCBI Full Name: | 3 beta-hydroxysteroid dehydrogenase/Delta 5--> |
NCBI Synonym Full Names: | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
NCBI Official Symbol: | HSD3B1 |
NCBI Official Synonym Symbols: | I; HSD3B; HSDB3; HSDB3A; SDR11E1; 3BETAHSD |
NCBI Protein Information: | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 |
UniProt Protein Name: | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 |
UniProt Synonym Protein Names: | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; Trophoblast antigen FDO161GIncluding the following 2 domains:3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC:1.1.1.145)Alternative name(s):3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase |
Protein Family: | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase |
UniProt Gene Name: | HSD3B1 |
UniProt Entry Name: | 3BHS1_HUMAN |
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