Anti-HSD17B3 Antibody (CAB7687)
- SKU:
- CAB7687
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-HSD17B3 Antibody |
抗体コード: | CAB7687 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human HSD17B3 (NP_000188.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Rat lung, Rat intestine |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human HSD17B3 (NP_000188.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MGDV LEQF FILT GLLV CLAC LAKC VRFS RCVL LNYW KVLP KSFL RSMG QWAV ITGA GDGI GKAY SFEL AKRG LNVV LISR TLEK LEAI ATEI ERTT GRSV KIIQ ADFT KDDI YEHI KEKL AGLE IGIL VNNV GMLP NLLP SHFL NAPD EIQS LIHC NITS VVKM TQLI LKHM ESRQ KGLI LNIS SGIA LFPW PLYS MYSA SKAF VCAF SKAL QEEY KAKE VIIQ VLTP YAVS TAMT KYLN TNVI TKTA DEFV KESL NYVT IGGE TCGC LAHE ILAG FLSL IPAW AFYS GAFQ RLLL THYV AYLK LNTK VR |
遺伝子ID: | 3293 |
Uniprot: | P37058 |
セルラーロケーション: | |
計算された分子量: | 29kDa/34kDa |
観察された分子量: | 34kDa |
同義語: | HSD17B3, EDH17B3, SDR12C2 |
バックグラウンド: | This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. |
UniProt Protein Function: | HSD17B3: Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. Defects in HSD17B3 are the cause of male pseudohermaphrodism with gynecomastia (MPH). These individuals have unambiguous female external genitalia at birth, but fail to menstruate at the time of expected puberty and instead virilize as evidenced by growth of the phallus. Breast development may or may not take place. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. |
UniProt Protein Details: | Protein type:EC 1.1.1.64; Oxidoreductase; Lipid Metabolism - androgen and estrogen Chromosomal Location of Human Ortholog: 9q22 Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle Molecular Function:testosterone 17-beta-dehydrogenase (NADP+) activity Biological Process: steroid metabolic process; male genitalia development; androgen biosynthetic process Disease: 17-beta Hydroxysteroid Dehydrogenase Iii Deficiency |
NCBI Summary: | This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008] |
UniProt Code: | P37058 |
NCBI GenInfo Identifier: | 4557649 |
NCBI Gene ID: | 3293 |
NCBI Accession: | NP_000188.1 |
UniProt Related Accession: | P37058 |
Molecular Weight: | 34,516 Da |
NCBI Full Name: | testosterone 17-beta-dehydrogenase 3 |
NCBI Synonym Full Names: | hydroxysteroid (17-beta) dehydrogenase 3 |
NCBI Official Symbol: | HSD17B3 |
NCBI Official Synonym Symbols: | EDH17B3; SDR12C2 |
NCBI Protein Information: | testosterone 17-beta-dehydrogenase 3; 17-beta-HSD3; 17-beta-HSD 3; 17-beta-hydroxysteroid dehydrogenase type 3; testicular 17-beta-hydroxysteroid dehydrogenase; short chain dehydrogenase/reductase family 12C, member 2 |
UniProt Protein Name: | Testosterone 17-beta-dehydrogenase 3 |
UniProt Synonym Protein Names: | 17-beta-hydroxysteroid dehydrogenase type 3; 17-beta-HSD 3; Testicular 17-beta-hydroxysteroid dehydrogenase |
Protein Family: | Testosterone 17-beta-dehydrogenase |
UniProt Gene Name: | HSD17B3 |
UniProt Entry Name: | DHB3_HUMAN |
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