Anti-HPD Antibody (CAB6505)
- SKU:
- CAB6505
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-HPD Antibody |
抗体コード: | CAB6505 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-393 of human HPD (NP_002141.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HL-60, Mouse liver, Mouse kidney, Rat liver, Rat kidney |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-393 of human HPD (NP_002141.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MTTY SDKG AKPE RGRF LHFH SVTF WVGN AKQA ASFY CSKM GFEP LAYR GLET GSRE VVSH VIKQ GKIV FVLS SALN PWNK EMGD HLVK HGDG VKDI AFEV EDCD YIVQ KARE RGAK IMRE PWVE QDKF GKVK FAVL QTYG DTTH TLVE KMNY IGQF LPGY EAPA FMDP LLPK LPKC SLEM IDHI VGNQ PDQE MVSA SEWY LKNL QFHR FWSV DDTQ VHTE YSSL RSIV VANY EESI KMPI NEPA PGKK KSQI QEYV DYNG GAGV QHIA LKTE DIIT AIRH LRER GLEF LSVP STYY KQLR EKLK TAKI KVKE NIDA LEEL KILV DYDE KGYL LQIF TKPV QDRP TLFL EVIQ RHNH QGFG AGNF NSLF KAFE EEQN LRGN LTNM ETNG VVPG M |
遺伝子ID: | 3242 |
Uniprot: | P32754 |
セルラーロケーション: | |
計算された分子量: | 40kDa/44kDa |
観察された分子量: | 45kDa |
同義語: | HPD, 4-HPPD, 4HPPD, GLOD3, HPPDASE, PPD |
バックグラウンド: | The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | HPD: Key enzyme in the degradation of tyrosine. Defects in HPD are the cause of tyrosinemia type 3 (TYRO3). TYRO3 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation. Defects in HPD are a cause of hawkinsinuria (HAWK). HAWK is an inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine. Belongs to the 4HPPD family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 1.13.11.27; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; Amino Acid Metabolism - phenylalanine; Oxidoreductase; Amino Acid Metabolism - tyrosine Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: cytosol Molecular Function:4-hydroxyphenylpyruvate dioxygenase activity; metal ion binding Biological Process: L-phenylalanine catabolic process; tyrosine catabolic process Disease: Hawkinsinuria; Tyrosinemia, Type Iii |
NCBI Summary: | The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] |
UniProt Code: | P32754 |
NCBI GenInfo Identifier: | 417144 |
NCBI Gene ID: | 3242 |
NCBI Accession: | P32754.2 |
UniProt Secondary Accession: | P32754,Q13234, A8K461, B3KQ63, |
UniProt Related Accession: | P32754 |
Molecular Weight: | 393 |
NCBI Full Name: | 4-hydroxyphenylpyruvate dioxygenase |
NCBI Synonym Full Names: | 4-hydroxyphenylpyruvate dioxygenase |
NCBI Official Symbol: | HPD |
NCBI Official Synonym Symbols: | PPD; 4HPPD; GLOD3; 4-HPPD; HPPDASE |
NCBI Protein Information: | 4-hydroxyphenylpyruvate dioxygenase; glyoxalase domain containing 3; 4-hydroxyphenylpyruvic acid oxidase |
UniProt Protein Name: | 4-hydroxyphenylpyruvate dioxygenase |
UniProt Synonym Protein Names: | 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase |
UniProt Gene Name: | HPD |
UniProt Entry Name: | HPPD_HUMAN |
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