Anti-HOXA11 Antibody (CAB2976)
- SKU:
- CAB2976
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
抗体名: | Anti-HOXA11 Antibody |
抗体コード: | CAB2976 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human HOXA11 (NP_005514.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human |
ポジティブサンプル: | SKOV3, HeLa, THP-1 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human HOXA11 (NP_005514.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MDFD ERGP CSSN MYLP SCTY YVSG PDFS SLPS FLPQ TPSS RPMT YSYS SNLP QVQP VREV TFRE YAIE PATK WHPR GNLA HCYS AEEL VHRD CLQA PSAA GVPG DVLA KSSA NVYH HPTP AVSS NFYS TVGR NGVL PQAF DQFF ETAY GTPE NLAS SDYP GDKS AEKG PPAA TATS AAAA |
遺伝子ID: | 3207 |
Uniprot: | P31270 |
セルラーロケーション: | Nucleus |
計算された分子量: | 34kDa |
観察された分子量: | 35kDa |
同義語: | HOXA11, HOX1, HOX1I, RUSAT1 |
バックグラウンド: | In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. |
UniProt Protein Function: | HOXA11: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXA11 are the cause of radioulnar synostosis with amegakaryocytic thrombocytopenia (RSAT). The syndrome consists of an unusual association of bone marrow failure and skeletal defects. Patients have the same skeletal defects, the proximal fusion of the radius and ulna, resulting in extremely limited pronation and supination of the forearm. Some patients have also symptomatic thrombocytopenia, with bruising and bleeding problems since birth, necessitating correction by bone marrow or umbilical-cord stem-cell transplantation. Belongs to the Abd-B homeobox family. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 7p15.2 Cellular Component: transcription factor complex; protein complex; nucleus Molecular Function:sequence-specific DNA binding Biological Process: embryonic forelimb morphogenesis; developmental growth; anatomical structure morphogenesis; transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription, DNA-dependent; male gonad development; uterus development; anterior/posterior pattern formation; positive regulation of chondrocyte differentiation; dorsal/ventral pattern formation; ureteric bud branching; single fertilization; induction of an organ; mesodermal cell fate specification; spermatogenesis; embryonic digit morphogenesis; skeletal development; metanephros development; proximal/distal pattern formation; embryonic limb morphogenesis Disease: Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia |
NCBI Summary: | In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008] |
UniProt Code: | P31270 |
NCBI GenInfo Identifier: | 13124744 |
NCBI Gene ID: | 3207 |
NCBI Accession: | P31270.2 |
UniProt Related Accession: | P31270 |
Molecular Weight: | |
NCBI Full Name: | Homeobox protein Hox-A11 |
NCBI Synonym Full Names: | homeobox A11 |
NCBI Official Symbol: | HOXA11 |
NCBI Official Synonym Symbols: | HOX1; HOX1I; RUSAT1 |
NCBI Protein Information: | homeobox protein Hox-A11 |
UniProt Protein Name: | Homeobox protein Hox-A11 |
UniProt Synonym Protein Names: | Homeobox protein Hox-1I |
UniProt Gene Name: | HOXA11 |
UniProt Entry Name: | HXA11_HUMAN |