Anti-HOPX Antibody (CAB15537)
- SKU:
- CAB15537
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-HOPX Antibody |
抗体コード: | CAB15537 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-73 of human HOPX (NP_631957.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:200 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | mouse brain, mouse lung, rat lung |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-73 of human HOPX (NP_631957.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSAE TASG PTED QVEI LEYN FNKV DKHP DSTT LCLI AAEA GLSE EETQ KWFK QRLA KWRR SEGL PSEC RSVT D |
遺伝子ID: | 84525 |
Uniprot: | Q9BPY8 |
セルラーロケーション: | Nucleus |
計算された分子量: | 8kDa/10kDa/12kDa |
観察された分子量: | 13kDa |
同義語: | HOPX, CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO |
バックグラウンド: | The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. |
UniProt Protein Function: | HOPX: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. May act as a tumor suppressor. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Oncoprotein; DNA-binding Chromosomal Location of Human Ortholog: 4q12 Cellular Component: nucleus Molecular Function:protein binding Biological Process: negative regulation of cell differentiation; regulation of transcription from RNA polymerase II promoter; trophectodermal cell differentiation |
NCBI Summary: | The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009] |
UniProt Code: | Q9BPY8 |
NCBI GenInfo Identifier: | 60392394 |
NCBI Gene ID: | 84525 |
NCBI Accession: | Q9BPY8.1 |
UniProt Secondary Accession: | Q9BPY8,Q8N0V6, Q96CI1, A8K0Z2, E9PB55, G3V294, |
UniProt Related Accession: | Q9BPY8 |
Molecular Weight: | 12,625 Da |
NCBI Full Name: | Homeodomain-only protein |
NCBI Synonym Full Names: | HOP homeobox |
NCBI Official Symbol: | HOPX |
NCBI Official Synonym Symbols: | HOD; HOP; OB1; LAGY; TOTO; CAMEO; NECC1; SMAP31 |
NCBI Protein Information: | homeodomain-only protein |
UniProt Protein Name: | Homeodomain-only protein |
UniProt Synonym Protein Names: | Lung cancer-associated Y protein; Not expressed in choriocarcinoma protein 1; Odd homeobox protein 1 |
Protein Family: | Homeodomain-only protein |
UniProt Gene Name: | HOPX |
UniProt Entry Name: | HOP_HUMAN |
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