Anti-HEY2 Antibody (CAB15143)
- SKU:
- CAB15143
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
抗体名: | Anti-HEY2 Antibody |
抗体コード: | CAB15143 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HEY2 (NP_036391.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | A-549, K562, MCF7, mouse brain, rat heart |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HEY2 (NP_036391.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MKRP CEET TSES DMDE TIDV GSEN NYSG QSTS SVIR LNSP TTTS QIMA RKKR RGII EKRR RDRI NNSL SELR RLVP TAFE KQGS AKLE KAEI LQMT VDHL |
遺伝子ID: | 23493 |
Uniprot: | Q9UBP5 |
セルラーロケーション: | Nucleus |
計算された分子量: | 35kDa |
観察された分子量: | 36kDa |
同義語: | HEY2, CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2, bHLHb32 |
バックグラウンド: | This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. |
UniProt Protein Function: | HEY2: Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Belongs to the HEY family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6q21 Cellular Component: cytoplasm; nucleoplasm; nucleus; Sin3 complex; transcriptional repressor complex Molecular Function:histone deacetylase binding; protein binding; protein dimerization activity; sequence-specific DNA binding; transcription factor activity; transcription factor binding Biological Process: anterior/posterior axis specification; cardiac muscle hypertrophy; cell fate commitment; mesenchymal cell development; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; Notch signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of heart rate; positive regulation of transcription from RNA polymerase II promoter; protein-DNA complex assembly; regulation of auditory receptor cell differentiation; smooth muscle cell differentiation; transcription, DNA-dependent; vasculogenesis; ventricular cardiac muscle cell development |
NCBI Summary: | This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UBP5 |
NCBI GenInfo Identifier: | 74762767 |
NCBI Gene ID: | 23493 |
NCBI Accession: | Q9UBP5.1 |
UniProt Secondary Accession: | Q9UBP5,Q9QUS4, |
UniProt Related Accession: | Q9UBP5 |
Molecular Weight: | 35,808 Da |
NCBI Full Name: | Hairy/enhancer-of-split related with YRPW motif protein 2 |
NCBI Synonym Full Names: | hes related family bHLH transcription factor with YRPW motif 2 |
NCBI Official Symbol: | HEY2 |
NCBI Official Synonym Symbols: | GRL; CHF1; HRT2; HERP1; HESR2; bHLHb32; GRIDLOCK |
NCBI Protein Information: | hairy/enhancer-of-split related with YRPW motif protein 2 |
UniProt Protein Name: | Hairy/enhancer-of-split related with YRPW motif protein 2 |
UniProt Synonym Protein Names: | Cardiovascular helix-loop-helix factor 1; hCHF1; Class B basic helix-loop-helix protein 32; bHLHb32; HES-related repressor protein 2; Hairy and enhancer of split-related protein 2; HESR-2; Hairy-related transcription factor 2; HRT-2; hHRT2; Protein gridlock homolog |
Protein Family: | Hairy/enhancer-of-split related with YRPW motif protein |
UniProt Gene Name: | HEY2 |
UniProt Entry Name: | HEY2_HUMAN |