Anti-HES6 Antibody (CAB16547)
- SKU:
- CAB16547
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
抗体名: | Anti-HES6 Antibody |
抗体コード: | CAB16547 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human HES6 (NP_061115.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | 293T |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human HES6 (NP_061115.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAPP AAPG RDRV GRED EDGW ETRG DRKA RKPL VEKK RRAR INES LQEL RLLL AGAE VQAK LENA EVLE LTVR RVQG VLRG RARE REQL QAEA SERF AAGY IQCM HEVH TFVS TCQA IDAT VAAE LLNH LLES MPLR EGSS FQDL LGDA LAGP PRAP GRSG WPAG GAPG SPIP SPPG PGDD LCSD LEEA PEAE LSQA PAEG PDLV PAAL GSLT TAQI ARSV WRPW |
遺伝子ID: | 55502 |
Uniprot: | Q96HZ4 |
セルラーロケーション: | Nucleus |
計算された分子量: | 12kDa/23kDa/24kDa |
観察された分子量: | 26kDa |
同義語: | HES6, C-HAIRY1, HES-6, bHLHb41, bHLHc23 |
バックグラウンド: | This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described. |
UniProt Protein Function: | HES6: Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: transcription factor complex Molecular Function:transcription cofactor activity; transcription factor activity Biological Process: regulation of transcription, DNA-dependent |
NCBI Summary: | This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008] |
UniProt Code: | Q96HZ4 |
NCBI GenInfo Identifier: | 50400609 |
NCBI Gene ID: | 55502 |
NCBI Accession: | Q96HZ4.1 |
UniProt Secondary Accession: | Q96HZ4,Q53SN9, Q8N2J2, Q96T93, Q9P2S3, A8KAP6, B8ZZA9 |
UniProt Related Accession: | Q96HZ4 |
Molecular Weight: | 12,240 Da |
NCBI Full Name: | Transcription cofactor HES-6 |
NCBI Synonym Full Names: | hes family bHLH transcription factor 6 |
NCBI Official Symbol: | HES6 |
NCBI Official Synonym Symbols: | HES-6; bHLHb41; bHLHc23; C-HAIRY1 |
NCBI Protein Information: | transcription cofactor HES-6 |
UniProt Protein Name: | Transcription cofactor HES-6 |
UniProt Synonym Protein Names: | C-HAIRY1; Class B basic helix-loop-helix protein 41; bHLHb41; Hairy and enhancer of split 6 |
Protein Family: | Transcription cofactor |
UniProt Gene Name: | HES6 |
UniProt Entry Name: | HES6_HUMAN |
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