Anti-HERC3 Antibody (CAB8567)
- SKU:
- CAB8567
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-HERC3 Antibody |
抗体コード: | CAB8567 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human HERC3 (NP_055421.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
反応性: | Human, Mouse |
ポジティブサンプル: | SH-SY5Y, U-87MG, A-431, Mouse lung, Mouse spinal cord |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human HERC3 (NP_055421.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MLCW GYWS LGQP GIST NLQG IVAE PQVC GFIS DRSV KEVA CGGN HSVF LLED GEVY TCGL NTKG QLGH EREG NKPE QIGA LADQ HIIH VACG ESHS LALS DRGQ LFSW GAGS DGQL GLMT TEDS VAVP RLIQ KLNQ QTIL QVSC GNWH CLAL AADG QFFT WGKN SHGQ LGLG KEFP SQAS PQRV RSLE GIPL AQVA AGGA |
遺伝子ID: | 8916 |
Uniprot: | Q15034 |
セルラーロケーション: | Cytoplasm, Cytoplasmic vesicle |
計算された分子量: | 39kDa/117kDa |
観察された分子量: | 117kDa |
同義語: | HERC3 |
バックグラウンド: | This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
UniProt Protein Function: | HERC3: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. |
UniProt Protein Details: | Protein type:Ligase; Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system; EC 6.3.2.- Chromosomal Location of Human Ortholog: 4q21 Cellular Component: cytoplasm; nucleus Molecular Function:ubiquitin-protein ligase activity Biological Process: protein ubiquitination during ubiquitin-dependent protein catabolic process |
NCBI Summary: | This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012] |
UniProt Code: | Q15034 |
NCBI GenInfo Identifier: | 2495699 |
NCBI Gene ID: | 8916 |
NCBI Accession: | Q15034.1 |
UniProt Secondary Accession: | Q15034,Q8IXX3, A8K1S5, |
UniProt Related Accession: | Q15034 |
Molecular Weight: | 39,051 Da |
NCBI Full Name: | Probable E3 ubiquitin-protein ligase HERC3 |
NCBI Synonym Full Names: | HECT and RLD domain containing E3 ubiquitin protein ligase 3 |
NCBI Official Symbol: | HERC3 |
NCBI Protein Information: | probable E3 ubiquitin-protein ligase HERC3 |
UniProt Protein Name: | Probable E3 ubiquitin-protein ligase HERC3 |
UniProt Synonym Protein Names: | HECT domain and RCC1-like domain-containing protein 3 |
Protein Family: | Probable E3 ubiquitin-protein ligase |
UniProt Gene Name: | HERC3 |
UniProt Entry Name: | HERC3_HUMAN |
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