Anti-HARS2 Antibody (CAB7785)
- SKU:
- CAB7785
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-HARS2 Antibody |
抗体コード: | CAB7785 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 217-506 of human HARS2 (NP_036340.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-251MG, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 217-506 of human HARS2 (NP_036340.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | IVDG MFAV CGVP ESKF RAIC SSID KLDK MAWK DVRH EMVV KKGL APEV ADRI GDYV QCHG GVSL VEQM FQDP RLSQ NKQA LEGL GDLK LLFE YLTL FGIA DKIS FDLS LARG LDYY TGVI YEAV LLQT PTQA GEEP LNVG SVAA GGRY DGLV GMFD PKGH KVPC VGLS IGVE RIFY IVEQ RMKT KGEK VRTT ETQV FVAT PQKN FLQE RLKL IAEL WDSG IKAE MLYK NNPK LLTQ LHYC ESTG IPLV VIIG EQEL KEGV IKIR SVAS REEV AIKR ENFV AEIQ KRLS ES |
遺伝子ID: | 23438 |
Uniprot: | P49590 |
セルラーロケーション: | Mitochondrion matrix |
計算された分子量: | 54kDa/56kDa |
観察された分子量: | 50kDa |
同義語: | HARS2, HARSL, HARSR, HO3, PRLTS2 |
バックグラウンド: | Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene. |
UniProt Protein Function: | HARS2: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter. [provided by RefSeq, Jul 2008] |
UniProt Protein Details: | Protein type:Aminoacyl-tRNA synthetase; EC 6.1.1.21; Ligase; Mitochondrial; Translation; Translation regulation Chromosomal Location of Human Ortholog: 5q31.3 Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:histidine-tRNA ligase activity; protein binding; protein homodimerization activity; RNA binding Biological Process: histidyl-tRNA aminoacylation; mitochondrial translation; tRNA aminoacylation for protein translation Disease: Perrault Syndrome 2 |
NCBI Summary: | Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] |
UniProt Code: | P49590 |
NCBI GenInfo Identifier: | 523567531 |
NCBI Gene ID: | 23438 |
NCBI Accession: | NP_001265660.1 |
UniProt Secondary Accession: | P49590,B4DDY8, |
UniProt Related Accession: | P49590 |
Molecular Weight: | 69.3kD |
NCBI Full Name: | probable histidine--tRNA ligase, mitochondrial isoform 2 |
NCBI Synonym Full Names: | histidyl-tRNA synthetase 2, mitochondrial |
NCBI Official Symbol: | HARS2 |
NCBI Official Synonym Symbols: | HO3; HARSL; HARSR; PRLTS2 |
NCBI Protein Information: | probable histidine--tRNA ligase, mitochondrial |
UniProt Protein Name: | Probable histidine--tRNA ligase, mitochondrial |
UniProt Synonym Protein Names: | Histidine--tRNA ligase-like; Histidyl-tRNA synthetase; HisRS |
Protein Family: | Probable histidine--tRNA ligase |
UniProt Gene Name: | HARS2 |
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