Anti-GUCY2C Antibody (CAB10562)
- SKU:
- CAB10562
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-GUCY2C Antibody |
抗体コード: | CAB10562 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-330 of human GUCY2C (NP_004954.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | HT-29, SW480, Mouse pancreas |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-330 of human GUCY2C (NP_004954.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | SQVS QNCH NGSY EISV LMMG NSAF AEPL KNLE DAVN EGLE IVRG RLQN AGLN VTVN ATFM YSDG LIHN SGDC RSST CEGL DLLR KISN AQRM GCVL IGPS CTYS TFQM YLDT ELSY PMIS AGSF GLSC DYKE TLTR LMSP ARKL MYFL VNFW KTND LPFK TYSW STSY VYKN GTET EDCF WYLN ALEA SVSY FSHE LGFK VVLR QDKE FQDI LMDH NRKS NVII MCGG PEFL YKLK GDRA VAED IVII LVDL FNDQ YFED NVTA PDYM KNVL VLTL SPGN SLLN SSFS RNLS PTKR DFAL AYLN GIL |
遺伝子ID: | 2984 |
Uniprot: | P25092 |
セルラーロケーション: | Cell membrane, Endoplasmic reticulum membrane, Single-pass type I membrane protein |
計算された分子量: | 123kDa |
観察された分子量: | 123kDa |
同義語: | GUCY2C, DIAR6, GC-C, GUC2C, MECIL, MUCIL, STAR |
バックグラウンド: | This gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive). |
UniProt Protein Function: | GUCY2C: an intestinal receptor for the E.coli enterotoxin, and the paracrine hormones guanylin and uroguanylin. Regulates intestinal cell proliferation. Converts guanosine-5'-triphosphate to cyclic guanosine monophosphate (cGMP). Elevated intracellular cGMP modulates intestinal fluid-ion homeostasis and differentiation of crypt enterocytes. cGMP inhibits colonic cell proliferation by inducing p21 and cell cycle arrest. mice lacking GC-C display increased cell proliferation in colonic crypts. It functions as a tumor suppressor; its loss disrupts intestinal homeostasis and promotes tumorigenesis. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. |
UniProt Protein Details: | Protein type:EC 4.6.1.2; Guanylyl cyclase; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); RGC family; RGC group; Receptor, misc. Chromosomal Location of Human Ortholog: 12p12.3 Cellular Component: guanylate cyclase complex, soluble; plasma membrane Molecular Function:adenylate cyclase activity; guanylate cyclase activity; protein binding Biological Process: cGMP biosynthetic process; digestion; receptor guanylyl cyclase signaling pathway Disease: Diarrhea 6; Meconium Ileus |
NCBI Summary: | This gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive). [provided by RefSeq, Nov 2016] |
UniProt Code: | P25092 |
NCBI GenInfo Identifier: | 311033390 |
NCBI Gene ID: | 2984 |
NCBI Accession: | P25092.2 |
UniProt Secondary Accession: | P25092,B2RMY6, |
UniProt Related Accession: | P25092 |
Molecular Weight: | 123kDa |
NCBI Full Name: | Heat-stable enterotoxin receptor |
NCBI Synonym Full Names: | guanylate cyclase 2C |
NCBI Official Symbol: | GUCY2C |
NCBI Official Synonym Symbols: | GC-C; STAR; DIAR6; GUC2C; MECIL; MUCIL |
NCBI Protein Information: | heat-stable enterotoxin receptor |
UniProt Protein Name: | Heat-stable enterotoxin receptor |
UniProt Synonym Protein Names: | Guanylyl cyclase C; GC-C; Intestinal guanylate cyclase |
Protein Family: | Heat-stable enterotoxin receptor |
UniProt Gene Name: | GUCY2C |
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