Anti-GRK1 Antibody (CAB6497)
- SKU:
- CAB6497
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
抗体名: | Anti-GRK1 Antibody |
抗体コード: | CAB6497 |
抗体サイズ: | 20uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human GRK1 (NP_002920.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Y79 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human GRK1 (NP_002920.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MDFG SLET VVAN SAFI AARG SFDG SSSQ PSRD KKYL AKLK LPPL SKCE SLRD SLSL EFES VCLE QPIG KKLF QQFL QSAE KHLP ALEL WKDI EDYD TADN DLQP QKAQ TILA QYLD PQAK LFCS FLDE GIVA KFKE GPVE IQDG LFQP LLQA TLAH LGQA |
遺伝子ID: | 6011 |
Uniprot: | Q15835 |
セルラーロケーション: | Lipid-anchor, Membrane |
計算された分子量: | 63kDa |
観察された分子量: | 65kDa |
同義語: | GRK1, GPRK1, RHOK, RK |
バックグラウンド: | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). |
UniProt Protein Function: | GRK1: a Ser/Thr of the GRK family. Phosphorylates and inactivates photon-activated rhodopsin. LOF mutations lead to type 2 Oguchi disease, a form of night blindness. A link between RHOK and retinitis pigmentosa is now thought to be unlikely |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; EC 2.7.11.14; Kinase, protein; AGC group; GRK family; GRK subfamily Chromosomal Location of Human Ortholog: 13q34 Molecular Function:G-protein coupled receptor kinase activity; rhodopsin kinase activity; ATP binding; protein kinase activity Biological Process: rhodopsin mediated signaling; post-embryonic retina morphogenesis in camera-type eye; phototransduction, visible light; regulation of rhodopsin mediated signaling; visual perception; protein amino acid autophosphorylation; photoreceptor cell morphogenesis; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of phosphorylation; negative regulation of apoptosis Disease: Oguchi Disease 2 |
NCBI Summary: | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008] |
UniProt Code: | Q15835 |
NCBI GenInfo Identifier: | 2833269 |
NCBI Gene ID: | 6011 |
NCBI Accession: | Q15835.1 |
UniProt Secondary Accession: | Q15835,Q53X14, |
UniProt Related Accession: | Q15835 |
Molecular Weight: | 563 |
NCBI Full Name: | Rhodopsin kinase |
NCBI Synonym Full Names: | G protein-coupled receptor kinase 1 |
NCBI Official Symbol: | GRK1 |
NCBI Official Synonym Symbols: | RK; RHOK; GPRK1 |
NCBI Protein Information: | rhodopsin kinase |
UniProt Protein Name: | Rhodopsin kinase |
UniProt Synonym Protein Names: | G protein-coupled receptor kinase 1 |
UniProt Gene Name: | GRK1 |
UniProt Entry Name: | RK_HUMAN |