Anti-GRHL2 Antibody (CAB10153)
- SKU:
- CAB10153
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-GRHL2 Antibody |
抗体コード: | CAB10153 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-250 of human GRHL2 (NP_079191.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | SH-SY5Y |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-250 of human GRHL2 (NP_079191.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | LSVS KASD SQED QEKR NCLG TSEA QSNL SGGE NRVQ VLKT VPVN LSLN QDHL ENSK REQY SISF PESS AIIP VSGI TVVK AEDF TPVF MAPP VHYP RGDG EEQR VVIF EQTQ YDVP SLAT HSAY LKDD QRST PDST YSES FKDA ATEK FRSA SVGA EEYM YDQT SSGT FQY |
遺伝子ID: | 79977 |
Uniprot: | Q6ISB3 |
セルラーロケーション: | Membrane, Nucleus |
計算された分子量: | 69kDa/71kDa |
観察された分子量: | 75kDa |
同義語: | GRHL2, BOM, DFNA28, ECTDS, TFCP2L3 |
バックグラウンド: | The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28). |
UniProt Protein Function: | GRHL2: May function as a transcription factor. Defects in GRHL2 are the cause of deafness autosomal dominant type 28 (DFNA28). DFNA28 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA28 is characterized by mild to moderate hearing loss across most frequencies that progressed to severe loss in the higher frequencies by the fifth decade. Age at onset varied, with the earliest case documented at 7 years of age. Belongs to the grh/CP2 family. Grainyhead subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 8q22.3 Cellular Component: intercellular junction; nucleoplasm; nucleus; plasma membrane Molecular Function:chromatin DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: brain development; cell adhesion; cell proliferation; epidermis development; negative regulation of keratinocyte differentiation; neural tube closure; neural tube development; positive regulation of telomerase activity; positive regulation of transcription from RNA polymerase II promoter Disease: Deafness, Autosomal Dominant 28; Ectodermal Dysplasia/short Stature Syndrome |
NCBI Summary: | The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).[provided by RefSeq, Mar 2009] |
UniProt Code: | Q6ISB3 |
NCBI GenInfo Identifier: | 74736618 |
NCBI Gene ID: | 79977 |
NCBI Accession: | Q6ISB3.1 |
UniProt Secondary Accession: | Q6ISB3,Q6NT03, Q9H8B8, A1L303, |
UniProt Related Accession: | Q6ISB3 |
Molecular Weight: | 69,322 Da |
NCBI Full Name: | Grainyhead-like protein 2 homolog |
NCBI Synonym Full Names: | grainyhead like transcription factor 2 |
NCBI Official Symbol: | GRHL2 |
NCBI Official Synonym Symbols: | BOM; ECTDS; DFNA28; TFCP2L3 |
NCBI Protein Information: | grainyhead-like protein 2 homolog |
UniProt Protein Name: | Grainyhead-like protein 2 homolog |
UniProt Synonym Protein Names: | Brother of mammalian grainyhead; Transcription factor CP2-like 3 |
Protein Family: | Grainyhead-like protein |
UniProt Gene Name: | GRHL2 |
UniProt Entry Name: | GRHL2_HUMAN |
View AllClose