Anti-GOT1 Antibody (CAB5822)
- SKU:
- CAB5822
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
抗体名: | Anti-GOT1 Antibody |
抗体コード: | CAB5822 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 244-413 of human GOT1 (NP_002070.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Jurkat, 293T, HepG2, A-549, HeLa, Mouse liver, Mouse kidney, Mouse heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 244-413 of human GOT1 (NP_002070.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | FVSE GFEF FCAQ SFSK NFGL YNER VGNL TVVG KEPE SILQ VLSQ MEKI VRIT WSNP PAQG ARIV ASTL SNPE LFEE WTGN VKTM ADRI LTMR SELR ARLE ALKT PGTW NHIT DQIG MFSF TGLN PKQV EYLV NEKH IYLL PSGR INVS GLTT KNLD YVAT SIHE AVTK IQ |
遺伝子ID: | 2805 |
Uniprot: | P17174 |
セルラーロケーション: | Cytoplasm |
計算された分子量: | 44kDa/46kDa |
観察された分子量: | 46kDa |
同義語: | GOT1, AST1, ASTQTL1, GIG18, cAspAT, cCAT |
バックグラウンド: | Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. |
UniProt Protein Function: | GOT1: Plays a key role in amino acid metabolism. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - arginine and proline; Transferase; EC 2.6.1.1; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - cysteine and methionine; EC 2.6.1.3; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - alanine, aspartate and glutamate Chromosomal Location of Human Ortholog: 10q24.1-q25.1 Cellular Component: lysosome; cytoplasm; nerve terminal; cytosol; nucleus Molecular Function:cysteine transaminase activity; carboxylic acid binding; phosphatidylserine decarboxylase activity; aspartate transaminase activity; pyridoxal phosphate binding Biological Process: glutamate metabolic process; oxaloacetate metabolic process; glutamate catabolic process to aspartate; response to glucocorticoid stimulus; aspartate biosynthetic process; glucose metabolic process; pathogenesis; 2-oxoglutarate metabolic process; gluconeogenesis; methionine salvage; cellular response to insulin stimulus; sulfur amino acid metabolic process; glycerol biosynthetic process; fatty acid homeostasis; carbohydrate metabolic process; aspartate catabolic process; aspartate metabolic process; amino acid biosynthetic process; glutamate catabolic process to 2-oxoglutarate; polyamine metabolic process Disease: Aspartate Aminotransferase, Serum Level Of, Quantitative Trait Locus 1 |
NCBI Summary: | Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008] |
UniProt Code: | P17174 |
NCBI GenInfo Identifier: | 5902703 |
NCBI Gene ID: | 2805 |
NCBI Accession: | P17174.3 |
UniProt Secondary Accession: | P17174,Q5VW80, B2R6R7, B7Z7E9, |
UniProt Related Accession: | P17174 |
Molecular Weight: | Calculated MW: 44kDa/46kDaObserved MW: 46kDa |
NCBI Full Name: | Aspartate aminotransferase, cytoplasmic |
NCBI Synonym Full Names: | glutamic-oxaloacetic transaminase 1, soluble |
NCBI Official Symbol: | GOT1 |
NCBI Official Synonym Symbols: | cCAT; GIG18; cAspAT; ASTQTL1 |
NCBI Protein Information: | aspartate aminotransferase, cytoplasmic; transaminase A; aspartate transaminase 1; aspartate aminotransferase 1; growth-inhibiting protein 18; cysteine transaminase, cytoplasmic; glutamate oxaloacetate transaminase 1; cysteine aminotransferase, cytoplasmic |
UniProt Protein Name: | Aspartate aminotransferase, cytoplasmic |
UniProt Synonym Protein Names: | Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A |
Protein Family: | Protein transport protein |
UniProt Gene Name: | GOT1 |
UniProt Entry Name: | AATC_HUMAN |