Anti-GNAT2 Antibody (CAB10352)
- SKU:
- CAB10352
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-GNAT2 Antibody |
抗体コード: | CAB10352 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human GNAT2 (NP_005263.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | HepG2 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human GNAT2 (NP_005263.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MGSG ASAE DKEL AKRS KELE KKLQ EDAD KEAK TVKL LLLG AGES GKST IVKQ MKII HQDG YSPE ECLE FKAI IYGN VLQS ILAI IRAM TTLG IDYA EPSC ADDG RQLN NLAD SIEE GTMP PELV EVIR RLWK DGGV QACF ERAA EYQL NDSA SYYL NQLE RITD PEYL PSEQ DVLR SRVK TTGI IETK FSVK DLNF RMFD VGGQ RSER KKWI HCFE GVTC |
遺伝子ID: | 2780 |
Uniprot: | P19087 |
セルラーロケーション: | |
計算された分子量: | 40kDa |
観察された分子量: | 45kDa |
同義語: | GNAT2, ACHM4, GNATC |
バックグラウンド: | Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. |
UniProt Protein Function: | G-alpha t2: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. Defects in GNAT2 are the cause of achromatopsia type 4 (ACHM4). Achromatopsia is an autosomal recessively inherited visual disorder that is present from birth and that features the absence of color discrimination. Belongs to the G-alpha family. G(i/o/t/z) subfamily. |
UniProt Protein Details: | Protein type:G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)); G protein Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: heterotrimeric G-protein complex; photoreceptor inner segment; photoreceptor outer segment; plasma membrane Molecular Function:G-protein beta/gamma-subunit binding; G-protein-coupled receptor binding; GTP binding; GTPase activity; signal transducer activity Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste; detection of light stimulus involved in visual perception; G-protein signaling, coupled to cAMP nucleotide second messenger; protein folding; Wnt receptor signaling pathway, calcium modulating pathway Disease: Achromatopsia 4 |
NCBI Summary: | Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008] |
UniProt Code: | P19087 |
NCBI GenInfo Identifier: | 232151 |
NCBI Gene ID: | 2780 |
NCBI Accession: | P19087.4 |
UniProt Related Accession: | P19087 |
Molecular Weight: | 40,176 Da |
NCBI Full Name: | Guanine nucleotide-binding protein G(t) subunit alpha-2 |
NCBI Synonym Full Names: | G protein subunit alpha transducin 2 |
NCBI Official Symbol: | GNAT2 |
NCBI Official Synonym Symbols: | ACHM4; GNATC |
NCBI Protein Information: | guanine nucleotide-binding protein G(t) subunit alpha-2 |
UniProt Protein Name: | Guanine nucleotide-binding protein G(t) subunit alpha-2 |
UniProt Synonym Protein Names: | Transducin alpha-2 chain |
UniProt Gene Name: | GNAT2 |
UniProt Entry Name: | GNAT2_HUMAN |
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