Anti-GITR Ligand/TNFSF18 Antibody (CAB7028)
- SKU:
- CAB7028
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
抗体名: | Anti-GITR Ligand/TNFSF18 Antibody |
抗体コード: | CAB7028 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 72-199 of human GITR Ligand/TNFSF18 (NP_005083.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SW620, SKOV3, Mouse skeletal muscle, Rat skeletal muscle |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 72-199 of human GITR Ligand/TNFSF18 (NP_005083.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | QLET AKEP CMAK FGPL PSKW QMAS SEPP CVNK VSDW KLEI LQNG LYLI YGQV APNA NYND VAPF EVRL YKNK DMIQ TLTN KSKI QNVG GTYE LHVG DTID LIFN SEHQ VLKN NTYW GIIL LANP QFIS |
遺伝子ID: | 8995 |
Uniprot: | Q9UNG2 |
セルラーロケーション: | Cell membrane, Single-pass type II membrane protein |
計算された分子量: | 22kDa |
観察された分子量: | 46kDa |
同義語: | TNFSF18, AITRL, GITRL, TL6, TNLG2A, hGITRL |
バックグラウンド: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. |
UniProt Protein Function: | TNFSF18: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Belongs to the tumor necrosis factor family. |
UniProt Protein Details: | Protein type:Apoptosis; Membrane protein, integral; Cytokine Chromosomal Location of Human Ortholog: 1q23 Cellular Component: extracellular space; cell surface; integral to membrane; plasma membrane Molecular Function:cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding; receptor binding Biological Process: cell-cell signaling; tumor necrosis factor-mediated signaling pathway; T cell proliferation during immune response; regulation of T cell proliferation; signal transduction; negative regulation of apoptosis; activation of NF-kappaB transcription factor |
NCBI Summary: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UNG2 |
NCBI GenInfo Identifier: | 325511353 |
NCBI Gene ID: | 8995 |
NCBI Accession: | Q9UNG2.2 |
UniProt Secondary Accession: | Q9UNG2,O95852, Q6ISV1, A9IQG8, |
UniProt Related Accession: | Q9UNG2 |
Molecular Weight: | 22,724 Da |
NCBI Full Name: | Tumor necrosis factor ligand superfamily member 18 |
NCBI Synonym Full Names: | tumor necrosis factor (ligand) superfamily, member 18 |
NCBI Official Symbol: | TNFSF18 |
NCBI Official Synonym Symbols: | TL6; AITRL; GITRL; hGITRL |
NCBI Protein Information: | tumor necrosis factor ligand superfamily member 18; AITR ligand; GITR ligand; activation-inducible TNF-related ligand; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand |
UniProt Protein Name: | Tumor necrosis factor ligand superfamily member 18 |
UniProt Synonym Protein Names: | Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL |
UniProt Gene Name: | TNFSF18 |
UniProt Entry Name: | TNF18_HUMAN |
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