Anti-GIT2 Antibody (CAB15368)
- SKU:
- CAB15368
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-GIT2 Antibody |
抗体コード: | CAB15368 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-510 of human GIT2 (NP_476511.1). |
申し込み: | WB |
推奨希釈: | WB 1:200 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | A-431, LO2, Jurkat, HeLa |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-510 of human GIT2 (NP_476511.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ASRL EKQN STPE SDYD NTPN DMEP DGMG SSRK GRQR SMVW PGDG LVPD TAEP HVAP SPTL P |
遺伝子ID: | 9815 |
Uniprot: | Q14161 |
セルラーロケーション: | |
計算された分子量: | 52kDa, 70-84kDa |
観察された分子量: | 84kDa |
同義語: | GIT2, CAT-2, CAT2, PKL |
バックグラウンド: | This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. |
UniProt Protein Function: | GIT2: possesses ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. Interacts with G protein-coupled receptor kinases. Associates with paxillin. Also interacts with PIX exchange factors. Regulates Golgi and actin cytoskeletal organization. Important in integrin-mediated cell adhesion. Ten alternatively spliced isoforms have been described and additional isoforms seem to exist. Contains 1 Arf-GAP domain and 3 ANK repeats. |
UniProt Protein Details: | Protein type:GAPs; GAPs, ARF; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 12q24.1 Cellular Component: focal adhesion; nucleoplasm Molecular Function:protein binding Biological Process: regulation of G-protein coupled receptor protein signaling pathway |
NCBI Summary: | This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008] |
UniProt Code: | Q14161 |
NCBI GenInfo Identifier: | 17376322 |
NCBI Gene ID: | 9815 |
NCBI Accession: | Q14161.2 |
UniProt Secondary Accession: | Q14161,Q86U59, Q96CI2, Q9BV91, Q9Y5V2, |
UniProt Related Accession: | Q14161 |
Molecular Weight: | 70,183 Da |
NCBI Full Name: | ARF GTPase-activating protein GIT2 |
NCBI Synonym Full Names: | GIT ArfGAP 2 |
NCBI Official Symbol: | GIT2 |
NCBI Official Synonym Symbols: | PKL; CAT2; CAT-2 |
NCBI Protein Information: | ARF GTPase-activating protein GIT2 |
UniProt Protein Name: | ARF GTPase-activating protein GIT2 |
UniProt Synonym Protein Names: | Cool-interacting tyrosine-phosphorylated protein 2; CAT-2; CAT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2 |
Protein Family: | ARF GTPase-activating protein |
UniProt Gene Name: | GIT2 |
UniProt Entry Name: | GIT2_HUMAN |
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