Anti-Gephyrin Antibody (CAB4729)
- SKU:
- CAB4729
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- GEPH
- Synonyms:
- GPH
- Synonyms:
- GPHRYN
- Synonyms:
- HKPX1
- Synonyms:
- MOCODC
Frequently bought together:
Description
| 抗体名: | Gephyrin Rabbit mAb |
| 抗体コード: | CAB4729 |
| サイズ: | 20uL, 50uL, 100uL |
| 同義語: | GEPH, GPH, GPHRYN, HKPX1, MOCODC |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human Gephyrin |
| 申し込み: | WB |
| 推奨される希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, HepG2, Mouse liver, Rat liver |
| 免疫原: | A synthesized peptide derived from human Gephyrin |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 10243 |
| Uniprot: | Q9NQX3 |
| セルラーロケーション: | Cell junction, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cytoskeleton, postsynaptic cell membrane, synapse |
| 計算された分子量: | 93kDa |
| 観察された分子量: | 93KDa |
| UniProt Protein Function: | gephyrin: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. Homotrimer. Interacts with GABARAP. Inhibited by copper and tungsten. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.7.7.75; Adaptor/scaffold; EC 2.10.1.1 Chromosomal Location of Human Ortholog: 14q23.3 Cellular Component: cytoplasm; dendrite; plasma membrane; postsynaptic membrane Molecular Function:protein binding Biological Process: Mo-molybdopterin cofactor biosynthetic process; molybdenum incorporation into molybdenum-molybdopterin complex; molybdopterin cofactor biosynthetic process Disease: Hyperekplexia, Hereditary 1; Molybdenum Cofactor Deficiency, Complementation Group C |
| NCBI Summary: | This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NQX3 |
| NCBI GenInfo Identifier: | 13431554 |
| NCBI Gene ID: | 10243 |
| NCBI Accession: | Q9NQX3.1 |
| UniProt Secondary Accession: | Q9NQX3,Q96KU4, Q9H4E9, Q9P2G2, |
| UniProt Related Accession: | Q9NQX3 |
| Molecular Weight: | 83,448 Da |
| NCBI Full Name: | Gephyrin |
| NCBI Synonym Full Names: | gephyrin |
| NCBI Official Symbol: | GPHN |
| NCBI Official Synonym Symbols: | GPH; GEPH; HKPX1; GPHRYN; MOCODC |
| NCBI Protein Information: | gephyrin |
| UniProt Protein Name: | Gephyrin |
| UniProt Synonym Protein Names: | Domain E |
| Protein Family: | Gephyrin |
| UniProt Gene Name: | GPHN |
| UniProt Entry Name: | GEPH_HUMAN |
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