Anti-GCNT3 Antibody (CAB13209)
- SKU:
- CAB13209
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
抗体名: | Anti-GCNT3 Antibody |
抗体コード: | CAB13209 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-180 of human GCNT3 (NP_004742.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | 293T, SGC-7901, U-87MG |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-180 of human GCNT3 (NP_004742.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | LKLS FRLK CDSD HLGL ESRE SQSQ YCRN ILYN FLKL PAKR SINC SGVT RGDQ EAVL QAIL NNLE VKKK REPF TDTH YLSL TRDC EHFK AERK FIQF PLSK EEVE FPIA YSMV IHEK IENF ERLL RAVY APQN IYCV HVDE KSPE TFKE AVKA II |
遺伝子ID: | 9245 |
Uniprot: | O95395 |
セルラーロケーション: | Golgi apparatus membrane, Single-pass type II membrane protein |
計算された分子量: | 50kDa |
観察された分子量: | 51kDa |
同義語: | GCNT3, C2/4GnT, C24GNT, C2GNT2, C2GNTM, GNTM |
バックグラウンド: | This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins. |
UniProt Protein Function: | GCNT3: Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. Belongs to the glycosyltransferase 14 family. |
UniProt Protein Details: | Protein type:EC 2.4.1.102; EC 2.4.1.150; Glycan Metabolism - O-glycan biosynthesis; Transferase; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q21.3 Cellular Component: Golgi membrane; membrane; integral to membrane Molecular Function:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; tissue morphogenesis; O-glycan processing; immunoglobulin production in mucosal tissue; carbohydrate metabolic process; post-translational protein modification; intestinal absorption |
NCBI Summary: | This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009] |
UniProt Code: | O95395 |
NCBI GenInfo Identifier: | 74735588 |
NCBI Gene ID: | 9245 |
NCBI Accession: | O95395.1 |
UniProt Related Accession: | O95395 |
Molecular Weight: | 50,864 Da |
NCBI Full Name: | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 |
NCBI Synonym Full Names: | glucosaminyl (N-acetyl) transferase 3, mucin type |
NCBI Official Symbol: | GCNT3 |
NCBI Official Synonym Symbols: | GNTM; C24GNT; C2GNT2; C2GNTM; C2/4GnT |
NCBI Protein Information: | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; hC2GnT-M; C2GnT-mucin type; beta1,6GlcNAc-transferase; beta1,6-N-acetylglucosaminyltransferase-M; core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase; mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase |
UniProt Protein Name: | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 |
UniProt Synonym Protein Names: | C2GnT-mucin type; C2GnT-M; hC2GnT-M; Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase; C2/4GnT |
Protein Family: | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
UniProt Gene Name: | GCNT3 |
UniProt Entry Name: | GCNT3_HUMAN |