Anti-GCH1 Antibody (CAB10616)
- SKU:
- CAB10616
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-GCH1 Antibody |
抗体コード: | CAB10616 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human GCH1 (NP_000152.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | THP-1, Mouse liver, Mouse brain, Mouse spleen, Rat lung, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human GCH1 (NP_000152.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MEKG PVRA PAEK PRGA RCSN GFPE RDPP RPGP SRPA EKPP RPEA KSAQ PADG WKGE RPRS EEDN ELNL PNLA AAYS SILS SLGE NPQR QGLL KTPW RAAS AMQF FTKG YQET ISDV LNDA IFDE DHDE MVIV KDID MFSM CEHH LVPF VGKV HIGY LPNK QVLG LSKL ARIV EIYS RRLQ VQER LTKQ IAVA ITEA LRPA GVGV VVEA THMC MVMR GVQK MNSK TVTS TMLG VFRE DPKT REEF LTLI RS |
遺伝子ID: | 2643 |
Uniprot: | P30793 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 23kDa/25kDa/27kDa |
観察された分子量: | 28KDa |
同義語: | GCH1, DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B |
バックグラウンド: | This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7, 8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. |
NCBI Summary: | This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008] |
UniProt Code: | P30793 |
NCBI GenInfo Identifier: | 399536 |
NCBI Gene ID: | 2643 |
NCBI Accession: | P30793.1 |
UniProt Related Accession: | P30793 |
Molecular Weight: | 27kDa |
NCBI Full Name: | GTP cyclohydrolase 1 |
NCBI Synonym Full Names: | GTP cyclohydrolase 1 |
NCBI Official Symbol: | GCH1 |
NCBI Official Synonym Symbols: | GCH; DYT5; DYT14; DYT5a; GTPCH1; HPABH4B; GTP-CH-1 |
NCBI Protein Information: | GTP cyclohydrolase 1 |
UniProt Protein Name: | GTP cyclohydrolase 1 |
UniProt Synonym Protein Names: | GTP cyclohydrolase I |
Protein Family: | GTP cyclohydrolase |
UniProt Gene Name: | GCH1 |
UniProt Entry Name: | GCH1_HUMAN |
View AllClose