Anti-GC Antibody (CAB5709)
- SKU:
- CAB5709
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-GC Antibody |
抗体コード: | CAB5709 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 324-493 of human GC (NP_001191236.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
反応性: | Human, Mouse |
ポジティブサンプル: | A-431, 293T, A-549, NCI-H460, A375, SH-SY5Y, Mouse liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 324-493 of human GC (NP_001191236.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | AMDV FVCT YFMP AAQL PELP DVEL PTNK DVCD PGNT KVMD KYTF ELSR RTHL PEVF LSKV LEPT LKSL GECC DVED STTC FNAK GPLL KKEL SSFI DKGQ ELCA DYSE NTFT EYKK KLAE RLKA KLPD ATPT ELAK LVNK HSDF ASNC CSIN SPPL YCDS EIDA ELKN IL |
遺伝子ID: | 2638 |
Uniprot: | P02774 |
セルラーロケーション: | Secreted |
計算された分子量: | 39kDa/52kDa/55kDa |
観察された分子量: | 60kDa |
同義語: | GC, DBP, DBP/GC, GRD3, Gc-MAF, GcMAF, HEL-S-51, VDBG, VDBP |
バックグラウンド: | The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | GC: Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. Belongs to the ALB/AFP/VDB family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 4q12-q13 Cellular Component: cytosol; extracellular region; extracellular space; lysosomal lumen Molecular Function:actin binding; vitamin D binding Biological Process: vitamin D metabolic process Disease: Graves Disease, Susceptibility To, 1 |
NCBI Summary: | The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011] |
UniProt Code: | P02774 |
NCBI GenInfo Identifier: | 139641 |
NCBI Gene ID: | 2638 |
NCBI Accession: | P02774.1 |
UniProt Secondary Accession: | P02774,Q16309, Q16310, Q53F31, Q6GTG1, B4DPP2, D6RAK8 |
UniProt Related Accession: | P02774 |
Molecular Weight: | 55,123 Da |
NCBI Full Name: | Vitamin D-binding protein |
NCBI Synonym Full Names: | GC, vitamin D binding protein |
NCBI Official Symbol: | GC |
NCBI Official Synonym Symbols: | DBP; GRD3; VDBG; VDBP; GcMAF; DBP/GC; Gc-MAF; HEL-S-51 |
NCBI Protein Information: | vitamin D-binding protein |
UniProt Protein Name: | Vitamin D-binding protein |
UniProt Synonym Protein Names: | Gc protein-derived macrophage activating factor |
Protein Family: | GCR1-dependent translation factor |
UniProt Gene Name: | GC |
UniProt Entry Name: | VTDB_HUMAN |
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