Anti-GBA2 Antibody (CAB12834)
- SKU:
- CAB12834
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-GBA2 Antibody |
抗体コード: | CAB12834 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 708-927 of human GBA2 (NP_065995.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | U-87MG, Mouse kidney, Mouse heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 708-927 of human GBA2 (NP_065995.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | AQDI QDKF SSIL SRGQ EAYE RLLW NGRY YNYD SSSR PQSR SVMS DQCA GQWF LKAC GLGE GDTE VFPT QHVV RALQ TIFE LNVQ AFAG GAMG AVNG MQPH GVPD KSSV QSDE VWVG VVYG LAAT MIQE GLTW EGFQ TAEG CYRT VWER LGLA FQTP EAYC QQRV FRSL AYMR PLSI WAMQ LALQ QQQH KKAS WPKV KQGT GLRT GPMF GPKE AMAN LSPE |
遺伝子ID: | 57704 |
Uniprot: | Q9HCG7 |
セルラーロケーション: | Cytoplasmic side, Endoplasmic reticulum membrane, Golgi apparatus membrane, Peripheral membrane protein |
計算された分子量: | 72kDa/98kDa/104kDa |
観察された分子量: | 105kDa |
同義語: | GBA2, AD035, NLGase, SPG46 |
バックグラウンド: | This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism. |
UniProt Protein Function: | GBA2: Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O- glucosides, however, the relevance of such activity is unclear in vivo. Belongs to the non-lysosomal glucosylceramidase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.2.1.45; Endoplasmic reticulum; Hydrolase; Membrane protein, integral Chromosomal Location of Human Ortholog: 9p13.3 Cellular Component: integral to membrane; plasma membrane; smooth endoplasmic reticulum Molecular Function:beta-glucosidase activity; glucosylceramidase activity Biological Process: bile acid metabolic process; central nervous system neuron development; glycoside catabolic process; glycosphingolipid metabolic process Disease: Spastic Paraplegia 46, Autosomal Recessive |
NCBI Summary: | This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9HCG7 |
NCBI GenInfo Identifier: | 143018392 |
NCBI Gene ID: | 57704 |
NCBI Accession: | Q9HCG7.2 |
UniProt Secondary Accession: | Q9HCG7,Q5TCV6, Q96A51, Q96LY1, Q96SJ2, Q9H2L8, D3DRP2 |
UniProt Related Accession: | Q9HCG7 |
Molecular Weight: | 105kDa |
NCBI Full Name: | Non-lysosomal glucosylceramidase |
NCBI Synonym Full Names: | glucosylceramidase beta 2 |
NCBI Official Symbol: | GBA2 |
NCBI Official Synonym Symbols: | AD035; SPG46; NLGase |
NCBI Protein Information: | non-lysosomal glucosylceramidase |
UniProt Protein Name: | Non-lysosomal glucosylceramidase |
UniProt Synonym Protein Names: | Beta-glucocerebrosidase 2; Beta-glucosidase 2; Glucosylceramidase 2 |
UniProt Gene Name: | GBA2 |
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