Anti-GART Antibody (CAB3876)
- SKU:
- CAB3876
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
抗体名: | Anti-GART Antibody |
抗体コード: | CAB3876 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human GART (NP_000810.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | U-87MG, HepG2, HeLa, K-562, Mouse liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human GART (NP_000810.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAAR VLII GSGG REHT LAWK LAQS HHVK QVLV APGN AGTA CSEK ISNT AISI SDHT ALAQ FCKE KKIE FVVV GPEA PLAA GIVG NLRS AGVQ CFGP TAEA AQLE SSKR FAKE FMDR HGIP TAQW KAFT KPEE ACSF ILSA DFPA LVVK ASGL AAGK GVIV AKSK EEAC KAVQ EIMQ EKAF GAAG ETIV IEEL LDGE EVSC LCFT DGKT VAPM PPAQ DHKR LLEG DGGP NTGG MGAY CPAP QVSN DLLL KIKD TVLQ RTVD GMQQ EGTP YTGI LYAG IMLT KNGP KVLE FNCR FGDP ECQV ILPL LKSD LYEV IQST LDGL |
遺伝子ID: | 2618 |
Uniprot: | P22102 |
セルラーロケーション: | |
計算された分子量: | 46kDa/107kDa |
観察された分子量: | 120kDa |
同義語: | GART, AIRS, GARS, GARTF, PAIS, PGFT, PRGS |
バックグラウンド: | The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. |
UniProt Protein Function: | GART: a highly conserved trifunctional enzyme. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. Inhibition of the de novo purine synthesis by folate analogs blocks the p53-dependent G1 checkpoint in human carcinoma cell lines. Two splice variant isoforms have been described. |
UniProt Protein Details: | Protein type:Methyltransferase; Ligase; EC 6.3.3.1; Nucleotide Metabolism - purine; EC 2.1.2.2; EC 6.3.4.13; Cofactor and Vitamin Metabolism - one carbon pool by folate; Mitochondrial; Enzyme, cellular metabolism Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: cytosol Molecular Function:methyltransferase activity; metal ion binding; phosphoribosylamine-glycine ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity; phosphoribosylglycinamide formyltransferase activity; ATP binding Biological Process: methylation; response to organic substance; purine ribonucleoside monophosphate biosynthetic process; glycine metabolic process; tetrahydrofolate biosynthetic process; response to inorganic substance; purine base biosynthetic process; nucleobase, nucleoside and nucleotide metabolic process; cerebellum development; cerebral cortex development; purine base metabolic process; 'de novo' IMP biosynthetic process |
NCBI Summary: | The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | P22102 |
NCBI GenInfo Identifier: | 131616 |
NCBI Gene ID: | 2618 |
NCBI Accession: | P22102.1 |
UniProt Related Accession: | P22102 |
Molecular Weight: | 120kDa |
NCBI Full Name: | Trifunctional purine biosynthetic protein adenosine-3 |
NCBI Synonym Full Names: | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase |
NCBI Official Symbol: | GART |
NCBI Official Synonym Symbols: | AIRS; GARS; PAIS; PGFT; PRGS; GARTF |
NCBI Protein Information: | trifunctional purine biosynthetic protein adenosine-3 |
UniProt Protein Name: | Trifunctional purine biosynthetic protein adenosine-3 |
UniProt Synonym Protein Names: | Glycinamide ribonucleotide synthetase; GARS; Phosphoribosylglycinamide synthetase |
UniProt Gene Name: | GART |
UniProt Entry Name: | PUR2_HUMAN |