Anti-GABRA2 Antibody (CAB1803)
- SKU:
- CAB1803
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-GABRA2 Antibody |
抗体コード: | CAB1803 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human GABRA2 (NP_000798.2). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | 22Rv1, Mouse brain |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human GABRA2 (NP_000798.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ARNS LPKV AYAT AMDW FIAV CYAF VFSA LIEF ATVN YFTK RGWA WDGK SVVN DKKK EKAS VMIQ NNAY AVAV ANYA PNLS KDPV LSTI SKSA TTPE PNKK P |
遺伝子ID: | 2555 |
Uniprot: | P47869 |
セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
計算された分子量: | 51kDa/52kDa |
観察された分子量: | 50kDa |
同義語: | GABRA2 |
バックグラウンド: | GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | GABRA2: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily. |
UniProt Protein Details: | Protein type:Transporter; Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral Chromosomal Location of Human Ortholog: 4p12 Cellular Component: postsynaptic membrane; axon; plasma membrane; cell junction; integral to synaptic vesicle membrane Molecular Function:chloride channel activity; GABA-A receptor activity; benzodiazepine receptor activity; extracellular ligand-gated ion channel activity Biological Process: synaptic transmission; neurotransmitter transport; regulation of neurotransmitter levels; transmembrane transport; gamma-aminobutyric acid signaling pathway Disease: Alcohol Dependence |
NCBI Summary: | GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] |
UniProt Code: | P47869 |
NCBI GenInfo Identifier: | 126302547 |
NCBI Gene ID: | 2555 |
NCBI Accession: | P47869.2 |
UniProt Secondary Accession: | P47869,Q59G14, A8K0U7, B7Z1H8, |
UniProt Related Accession: | P47869 |
Molecular Weight: | 451 |
NCBI Full Name: | Gamma-aminobutyric acid receptor subunit alpha-2 |
NCBI Synonym Full Names: | gamma-aminobutyric acid (GABA) A receptor, alpha 2 |
NCBI Official Symbol: | GABRA2 |
NCBI Protein Information: | gamma-aminobutyric acid receptor subunit alpha-2; GABA(A) receptor, alpha 2; GABA(A) receptor subunit alpha-2 |
UniProt Protein Name: | Gamma-aminobutyric acid receptor subunit alpha-2 |
UniProt Synonym Protein Names: | GABA(A) receptor subunit alpha-2 |
Protein Family: | Gamma-aminobutyric acid receptor |
UniProt Gene Name: | GABRA2 |
UniProt Entry Name: | GBRA2_HUMAN |
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