Anti-Frizzled-9 Antibody (CAB8311)
- SKU:
- CAB8311
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | FZD9 Rabbit Polyclonal Antibody |
抗体コード: | CAB8311 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 469-591 of human FZD9 (NP_003499.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | TE-1, 293T, HepG2, THP-1, U-251MG, Mouse heart, Mouse brain, Rat skeletal muscle |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 469-591 of human FZD9 (NP_003499.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ERLN MDFW RLRA TEQP CAAA AGPG GRRD CSLP GGSV PTVA VFML KIFM SLVV GITS GVWV WSSK TFQT WQSL CYRK IAAG RARA KACR APGS YGRG THCH YKAP TVVL HMTK TDPS LENP THL |
遺伝子ID: | 8326 |
Uniprot: | O00144 |
セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
計算された分子量: | 64kDa |
観察された分子量: | 80kDa |
同義語: | FZD9, CD349, FZD3 |
バックグラウンド: | Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. |
UniProt Protein Function: | FZD9: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family. |
UniProt Protein Details: | Protein type:GPCR, Fz/Smo family; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: cell surface; cytoplasm; plasma membrane Molecular Function:G-protein coupled receptor activity; protein heterodimerization activity; protein homodimerization activity; Wnt-protein binding Biological Process: nervous system development; Wnt receptor signaling pathway through beta-catenin |
NCBI Summary: | Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00144 |
NCBI GenInfo Identifier: | 17432964 |
NCBI Gene ID: | 8326 |
NCBI Accession: | O00144.1 |
UniProt Related Accession: | O00144 |
Molecular Weight: | 64,466 Da |
NCBI Full Name: | Frizzled-9 |
NCBI Synonym Full Names: | frizzled class receptor 9 |
NCBI Official Symbol: | FZD9 |
NCBI Official Synonym Symbols: | FZD3; CD349 |
NCBI Protein Information: | frizzled-9 |
UniProt Protein Name: | Frizzled-9 |
UniProt Synonym Protein Names: | FzE6; CD_antigen: CD349 |
Protein Family: | Frizzled |
UniProt Gene Name: | FZD9 |
UniProt Entry Name: | FZD9_HUMAN |
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