Anti-Caspase-9 Antibody (CAB4919)

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SKU:
CAB4919
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
APAF-3
Synonyms:
APAF3
Synonyms:
ICE-LAP6
Synonyms:
MCH6
Synonyms:
PPP1R56
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Description

I抗体名:Caspase-9 Rabbit mAb
抗体コード:CAB4919
サイズ:20uL, 50uL, 100uL
同義語:APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56
申し込み:WB
反応性:Human
宿主種:Rabbit
免疫原:A synthesized peptide derived from human Caspase-9
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human
ポジティブサンプル:Jurkat, 293T
免疫原:A synthesized peptide derived from human Caspase-9
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:842
Uniprot:P55211
計算された分子量:46kDa
観察された分子量:47KDa
UniProt Protein Function:CASP9: a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two isoforms.
UniProt Protein Details:

Protein type:Apoptosis; EC 3.4.22.62; Protease

Chromosomal Location of Human Ortholog: 1p36.21

Cellular Component: apoptosome; cytosol

Molecular Function:cysteine-type endopeptidase activity; enzyme activator activity; peptidase activity; protein binding; protein kinase binding; SH3 domain binding

Biological Process: apoptosis; caspase activation via cytochrome c; DNA damage response, signal transduction; DNA damage response, signal transduction resulting in induction of apoptosis; platelet formation; response to DNA damage stimulus

NCBI Summary:This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
UniProt Code:P55211
NCBI GenInfo Identifier:28558771
NCBI Gene ID:842
NCBI Accession:P55211.3
UniProt Secondary Accession:P55211,O95348, Q53Y70, Q5JRU9, Q5UGI1, Q92852, Q9BQ62 Q9UEQ3, Q9UIJ8, B4E1A3,
UniProt Related Accession:P55211
Molecular Weight:
NCBI Full Name:Caspase-9
NCBI Synonym Full Names:caspase 9
NCBI Official Symbol:CASP9  
NCBI Official Synonym Symbols:MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6  
NCBI Protein Information:caspase-9
UniProt Protein Name:Caspase-9
UniProt Synonym Protein Names:Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3
Protein Family:Caspase
UniProt Gene Name:CASP9  
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