Anti-FOXD3 Antibody (CAB2926)
- SKU:
- CAB2926
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-FOXD3 Antibody |
抗体コード: | CAB2926 |
抗体サイズ: | 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | A synthetic peptide of human FOXD3 |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa |
免疫原: | A synthetic peptide of human FOXD3 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 27022 |
Uniprot: | Q9UJU5 |
セルラーロケーション: | Nucleus |
計算された分子量: | 47kDa |
観察された分子量: | 48kDa |
同義語: | FOXD3, AIS1, Genesis, HFH2, VAMAS2 |
バックグラウンド: | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. |
UniProt Protein Function: | FOXD3: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 1p31.3 Cellular Component: nucleoplasm; nuclear chromatin Molecular Function:protein binding; double-stranded DNA binding; transcription factor activity Biological Process: embryonic placenta development; transcription, DNA-dependent; somatic stem cell maintenance; in utero embryonic development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; trophectodermal cell differentiation Disease: Autoimmune Disease, Susceptibility To, 1 |
NCBI Summary: | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008] |
UniProt Code: | Q9UJU5 |
NCBI GenInfo Identifier: | 8134475 |
NCBI Gene ID: | 27022 |
NCBI Accession: | Q9UJU5.1 |
UniProt Secondary Accession: | Q9UJU5,Q9BYM2, Q9UDD1, |
UniProt Related Accession: | Q9UJU5 |
Molecular Weight: | 478 |
NCBI Full Name: | Forkhead box protein D3 |
NCBI Synonym Full Names: | forkhead box D3 |
NCBI Official Symbol: | FOXD3 |
NCBI Official Synonym Symbols: | AIS1; HFH2; VAMAS2; Genesis |
NCBI Protein Information: | forkhead box protein D3; HNF3/FH transcription factor genesis |
UniProt Protein Name: | Forkhead box protein D3 |
UniProt Synonym Protein Names: | HNF3/FH transcription factor genesis |
Protein Family: | Forkhead box protein |
UniProt Gene Name: | FOXD3 |
UniProt Entry Name: | FOXD3_HUMAN |
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