Anti-FIP1L1 Antibody (CAB5016)

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SKU:
CAB5016
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
FIP1L1
Synonyms:
FIP1
Synonyms:
Rhe
Synonyms:
hFip1
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Description

抗体名:FIP1L1 Rabbit pAb
抗体コード:CAB5016
サイズ:20uL, 50uL, 100uL
同義語:FIP1L1, FIP1, Rhe, hFip1
申し込み:WB, IF
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant protein of human FIP1L1
申し込み:WB, IF
推奨される希釈:WB 1:500 - 1:2000 IF 1:50 - 1:100
反応性:Human, Mouse, Rat
ポジティブサンプル:293T, Mouse thymus, Rat lung
免疫原:Recombinant protein of human FIP1L1
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MSAG EVER LVSE LSGG TGGD EEEE WLYG DENE VERP EEEN ASAN PPSG IEDE TAEN GVPK PKVT ETED DSDS DSDD DEDD VHVT IGDI KTGA PQYG SYGT APVN LNIK TGGR VYGT TGTK VKGV DLDA PGSI NGVP LLEV DLDS FEDK PWRK PGAD LSDY FNYG FNED TWKA YCEK QKRI RMGL EVIP VTST TNKI TAED CTME VTPG AEIQ DGRF NLFK VQQG RTGN SEKE TALP STKA EFTS PPSL FKTG LPPS RNST SSQS QTST ASRK ANSS VGKW QDRY GRAE SPDL RRLP GAID
遺伝子ID:81608
Uniprot:Q6UN15
セルラーロケーション:Nucleus
計算された分子量:40kDa/58kDa/65kDa/66kDa
観察された分子量:75kDa
UniProt Protein Function:FIP1L1: a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. A fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA) is the cause of some cases of hypereosinophilic syndrome (HES), a disorder characterized by overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage. Four alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:RNA processing; RNA-binding

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: nucleoplasm; mRNA cleavage and polyadenylation specificity factor complex

Biological Process: mRNA processing

Disease: Hypereosinophilic Syndrome, Idiopathic

NCBI Summary:This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
UniProt Code:Q6UN15
NCBI GenInfo Identifier:74749365
NCBI Gene ID:81608
NCBI Accession:Q6UN15.1
UniProt Related Accession:Q6UN15
Molecular Weight:75kDa
NCBI Full Name:Pre-mRNA 3'-end-processing factor FIP1
NCBI Synonym Full Names:factor interacting with PAPOLA and CPSF1
NCBI Official Symbol:FIP1L1  
NCBI Official Synonym Symbols:Rhe; FIP1; hFip1  
NCBI Protein Information:pre-mRNA 3'-end-processing factor FIP1
UniProt Protein Name:Pre-mRNA 3'-end-processing factor FIP1
UniProt Synonym Protein Names:FIP1-like 1 protein; Factor interacting with PAP; Rearranged in hypereosinophilia
Protein Family:Pre-mRNA 3'-end-processing factor
UniProt Gene Name:FIP1L1  
UniProt Entry Name:FIP1_HUMAN
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