Anti-FEZ1 Antibody (CAB15362)
- SKU:
- CAB15362
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-FEZ1 Antibody |
抗体コード: | CAB15362 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human FEZ1 (NP_005094.1). |
申し込み: | WB |
推奨希釈: | WB 1:200 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse brain, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human FEZ1 (NP_005094.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MEAP LVSL DEEF EDLR PSCS EDPE EKPQ CFYG SSPH HLED PSLS ELEN FSSE IISF KSME DLVN EFDE KLNV CFRN YNAK TENL APVK NQLQ IQEE EETL QDEE VWDA LTDN YIPS LSED WRDP NIEA LNGN CSDT EIHE KEEE EFNE KSEN DSGI NEEP |
遺伝子ID: | 9638 |
Uniprot: | Q99689 |
セルラーロケーション: | Cell membrane, Cytoplasm, centrosome, cytoskeleton, microtubule organizing center |
計算された分子量: | 12kDa/45kDa |
観察された分子量: | 62kDa |
同義語: | FEZ1, UNC-76 |
バックグラウンド: | This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. |
UniProt Protein Function: | FEZ1: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. Belongs to the zygin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 11q24.2 Cellular Component: microtubule cytoskeleton; centrosome; microtubule; mitochondrion; axon; cytoplasm; dendrite; plasma membrane Molecular Function:protein binding; gamma-tubulin binding; protein kinase C binding; protein N-terminus binding Biological Process: establishment of mitochondrion localization; axon guidance; nervous system development; transport; cell adhesion |
NCBI Summary: | This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99689 |
NCBI GenInfo Identifier: | 13431526 |
NCBI Gene ID: | 9638 |
NCBI Accession: | Q99689.1 |
UniProt Secondary Accession: | Q99689,O00679, O00728, Q6IBI7, |
UniProt Related Accession: | Q99689 |
Molecular Weight: | 12,074 Da |
NCBI Full Name: | Fasciculation and elongation protein zeta-1 |
NCBI Synonym Full Names: | fasciculation and elongation protein zeta 1 (zygin I) |
NCBI Official Symbol: | FEZ1 |
NCBI Protein Information: | fasciculation and elongation protein zeta-1; zygin I; zygin-1 |
UniProt Protein Name: | Fasciculation and elongation protein zeta-1 |
UniProt Synonym Protein Names: | Zygin I; Zygin-1 |
Protein Family: | Fasciculation and elongation protein |
UniProt Gene Name: | FEZ1 |
UniProt Entry Name: | FEZ1_HUMAN |
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