Anti-FBXO32 Antibody (CAB11439)
- SKU:
- CAB11439
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-FBXO32 Antibody |
| 抗体コード: | CAB11439 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human FBXO32 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:500 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse ovary |
| 免疫原: | Recombinant protein of human FBXO32 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 114907 |
| Uniprot: | Q969P5 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 30kDa/41kDa |
| 観察された分子量: | 42kDa |
| 同義語: | FBXO32, Fbx32, MAFbx |
| バックグラウンド: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | FBXO32: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 8q24.13 Cellular Component: nucleolus; Z disc Molecular Function:protein binding Biological Process: protein ubiquitination; response to denervation involved in regulation of muscle adaptation |
| NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] |
| UniProt Code: | Q969P5 |
| NCBI GenInfo Identifier: | 20177894 |
| NCBI Gene ID: | 114907 |
| NCBI Accession: | Q969P5.1 |
| UniProt Secondary Accession: | Q969P5,A4KYM0, |
| UniProt Related Accession: | Q969P5 |
| Molecular Weight: | 355 |
| NCBI Full Name: | F-box only protein 32 |
| NCBI Synonym Full Names: | F-box protein 32 |
| NCBI Official Symbol: | FBXO32 |
| NCBI Official Synonym Symbols: | Fbx32; MAFbx |
| NCBI Protein Information: | F-box only protein 32; atrogin 1; atrogin-1; muscle atrophy F-box protein |
| UniProt Protein Name: | F-box only protein 32 |
| UniProt Synonym Protein Names: | Atrogin-1; Muscle atrophy F-box protein; MAFbx |
| UniProt Gene Name: | FBXO32 |
| UniProt Entry Name: | FBX32_HUMAN |
 | Western blot analysis of extracts of mouse ovary, using FBXO32 antibody (CAB11439) at 1:200 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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