Anti-FBP1 Antibody (CAB11664)
- SKU:
- CAB11664
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Metabolism
Description
抗体名: | Anti-FBP1 Antibody |
抗体コード: | CAB11664 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human FBP1 |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | MCF7 |
免疫原: | A synthesized peptide derived from human FBP1 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 2203 |
Uniprot: | P09467 |
セルラーロケーション: | |
計算された分子量: | 37 kDa |
観察された分子量: | 40KDa |
同義語: | FBP |
バックグラウンド: | Fructose-1, 6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1, 6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1, 6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008] |
UniProt Protein Function: | FBPase: a key enzyme of gluconeogenesis that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate, a precursor to glucose 6-phosphate. A regulator of glucose synthesis from non-carbohydrates. Two paralogs of this enzyme exists in humans, FBP1 in the liver and FBP2 in muscle. While both forms are inhibited allosterically by AMP, NAD and Ca2+, the muscle form is about 100-fold more sensitive to AMP and NAD, and about 1000-fold more sensitive to inhibition by Ca2+. Forms homotetramers that are stabilized in the active state by divalent cations (Mg2+, Mn2+ , Co+2, or Zn2+). Deficiency of FBP1 leads to a disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children. |
UniProt Protein Details: | Protein type:Phosphatase (non-protein); Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Carbohydrate Metabolism - fructose and mannose; Mitochondrial; Carbohydrate Metabolism - glycolysis and gluconeogenesis Chromosomal Location of Human Ortholog: 9q22.3 Cellular Component: cytoplasm; cytosol Molecular Function:monosaccharide binding; identical protein binding; protein binding; metal ion binding; fructose-bisphosphatase activity; AMP binding Biological Process: dephosphorylation; carbohydrate metabolic process; negative regulation of Ras protein signal transduction; glucose metabolic process; regulation of gluconeogenesis; pathogenesis; negative regulation of cell growth; negative regulation of glycolysis; fructose 6-phosphate metabolic process; protein homotetramerization; fructose metabolic process; gluconeogenesis Disease: Fructose-1,6-bisphosphatase Deficiency |
NCBI Summary: | Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008] |
UniProt Code: | P09467 |
NCBI GenInfo Identifier: | 311033495 |
NCBI Gene ID: | 2203 |
NCBI Accession: | P09467.5 |
UniProt Secondary Accession: | P09467,O75571, Q53F94, Q96E46, |
UniProt Related Accession: | P09467 |
Molecular Weight: | 338 |
NCBI Full Name: | Fructose-1,6-bisphosphatase 1 |
NCBI Synonym Full Names: | fructose-1,6-bisphosphatase 1 |
NCBI Official Symbol: | FBP1 |
NCBI Official Synonym Symbols: | FBP |
NCBI Protein Information: | fructose-1,6-bisphosphatase 1; FBPase 1; liver FBPase; fructose-bisphosphatase 1; growth-inhibiting protein 17; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 |
UniProt Protein Name: | Fructose-1,6-bisphosphatase 1 |
UniProt Synonym Protein Names: | D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; Liver FBPase |
Protein Family: | Fat-body protein |
UniProt Gene Name: | FBP1 |
UniProt Entry Name: | F16P1_HUMAN |